+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Short-term effects of GH treatment on coagulation, fibrinolysis, inflammation biomarkers, and insulin resistance status in prepubertal children with GH deficiency

Short-term effects of GH treatment on coagulation, fibrinolysis, inflammation biomarkers, and insulin resistance status in prepubertal children with GH deficiency

European Journal of Endocrinology 167(2): 255-260

The aims of this study was to determine whether prepubertal GH deficiency (GHD) children showed any impairment in coagulation- and fibrinolysis-related parameters and in inflammatory and insulin resistance markers and to evaluate the effect of short-term GH therapy on these parameters. This was a 6-month, prospective, observational, case–control study (36 prepubertal children with GHD and 38 healthy prepubertal children with no differences in BMI). Comparison of study parameter values in GHD and control groups at baseline and after 6 months of GH treatment in the GHD group. The following were analyzed: glucose, insulin, fibrinogen, absolute plasminogen activator inhibitor type 1 (aPAI-1), von Willebrand factor (vWF), homeostasis model assessment for insulin resistance (HOMA-IR) index, C-reactive protein (CRP), and interleukin 6 (IL6) levels. Children with GHD showed higher baseline levels of aPAI-1 and fibrinogen and lower levels of glucose, insulin, and HOMA-IR index than healthy controls. No intergroup differences were found for vWF. After 6 months of treatment, aPAI-1 levels were lower but no changes were observed in fibrinogen or vWF levels, which were similar to those of controls. Glucose levels increased, though not significantly, while insulin levels and HOMA-IR index rose to normal levels. A positive correlation was found between changes in insulin status/HOMA-IR index and levels of aPAI-1, fibrinogen, vWF, CRP, and IL6. At early ages, GH therapy appears to exert beneficial effects on the amount of aPAI-At the same time, it increases the state of insulin resistance (HOMA-IR index) without modifying the levels of fibrinogen, vWF, CRP, and IL6.

(PDF emailed within 0-6 h: $19.90)

Accession: 036501497

Download citation: RISBibTeXText

PMID: 22645201

DOI: 10.1530/EJE-12-0214

Related references

Short-term Effects of Diet and Activity Changes on Inflammation and Insulin Resistance. International Journal of Sports Medicine 37(13): 1032-1037, 2016

Response of biomarkers of inflammation and coagulation to short-term changes in central site, local, and predicted particle number concentrations. Annals of Epidemiology 25(7): 505-511, 2016

Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. Metabolism: Clinical and Experimental 55(1): 72-77, 2005

Efficacy of short-term growth hormone treatment in prepubertal children with idiopathic short stature. Yonsei Medical Journal 55(1): 53-60, 2014

Association of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes. Folia Medica 54(2): 32-39, 2012

Sex-Specific Mediating Role of Insulin Resistance and Inflammation in the Effect of Adiposity on Blood Pressure of Prepubertal Children. Plos One 10(6): E0132097-E0132097, 2016

Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function. European Journal of Endocrinology 162(2): 281-288, 2010

Plasma levels of insulin-like binding protein-2 in prepubertal short children and its diagnostic value in the evaluation of growth hormone deficiency. Hormone Research 55(3): 147-154, 2001

A partial transient effect of short-term growth hormone (GH) treatment in short non-GH deficient prepubertal children. Journal of Pediatric Endocrinology & Metabolism 8(3): 173-179, 1995

Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. Blood Coagulation & Fibrinolysis 25(4): 349-352, 2015

Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Critical Care 12(2): R41-R41, 2008

Short-term changes in bone formation markers following growth hormone (GH) treatment in short prepubertal children with a broad range of GH secretion. Clinical Endocrinology 82(1): 91-99, 2015

Metabolic outcome of GH treatment in prepubertal short children with and without classical GH deficiency. Clinical Endocrinology 73(3): 346-354, 2011

Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metabolic Syndrome and Related Disorders 10(6): 422-429, 2013

Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 60(10): 2474-2483, 2011