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Neoadjuvant chemotherapy plus radical surgery followed by chemotherapy in locally advanced cervical cancer



Neoadjuvant chemotherapy plus radical surgery followed by chemotherapy in locally advanced cervical cancer



Gynecologic Oncology 125(supp-S1): 0-0



To evaluate the efficacy, in terms of safety, overall survival and progression free survival of neoadjuvant chemotherapy followed by radical surgery plus adjuvant chemotherapy in patients affected by locally advanced cervical cancer (Stage IB2-IIB) with or without node metastases. Between June 2 to May 27, all patients with diagnosis of locally advanced cervical cancer referred to the Division of Gynecologic Oncology of the University Campus Bio-Medico of Rome were eligible for this protocol. All enrolled patients received 3 cycles of platinum-based chemotherapy every 3weeks according to the scheme Cisplatin 1mg/mq and Paclitaxel 175mg/mq. After neoadjuvant chemotherapy all patients with stable or progressive disease were excluded from the protocol, the others were submitted to classical radical hysterectomy, bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy and 4 cycles of adjuvant treatment with platinum based chemotherapy were executed. Concerning intention to treat basis analysis, 5years overall survival (OS) and disease-free survival (DFS) are 77% and 61%, respectively. The 5-years OS of patients with positive pelvic nodes and those with negative nodes metastases was respectively 6% and 87%. Concerning the according to protocol analysis, the 5-years OS and DFS are 81% and 7% respectively. The 5-years OS in patient with positive and negative lymphonodes is 75% and 88% respectively. The adjuvant chemotherapy regimen after neoadjuvant chemotherapy and radical surgery represents a valid treatment for patients with locally advanced cervical cancer. NACT+RS+adjuvant chemotherapy may be an option for locally advanced cervical cancer, in terms of survival. NACT+RS+adjuvant chemotherapy as initial treatment leaves radiotherapy in reserve should the patient relapse or non-respond to chemotherapy.

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Accession: 036502510

Download citation: RISBibTeXText

PMID: 22819938

DOI: 10.1016/j.ygyno.2011.12.004


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