The glycated albumin to glycated haemoglobin ratio increases along with the fibrosis stage in non-alcoholic steatohepatitis

Bando, Y.; Kanehara, H.; Aoki, K.; Toya, D.; Notsumata, K.; Tanaka, N.; Enomoto, H.; Nishiguchi, S.-h.; Nakasho, K.; Nakamura, H.; Kasayama, S.; Koga, M.

Annals of Clinical Biochemistry 49(Part 4): 387-390


ISSN/ISBN: 1758-1001
PMID: 22715293
DOI: 10.1258/acb.2012.011139
Accession: 036508708

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We previously reported that the indicator of glycaemic control, glycated albumin (GA) levels, are low in relation to glycaemia in patients with high alanine aminotransferase (ALT) levels in non-alcoholic fatty liver disease because of chronic inflammation, and that the GA/glycated haemoglobin ratio (G/H ratio) is inversely correlated with hepatic function in patients with chronic liver disease. The severity of liver fibrosis is known to be a good indicator for surveillance, and for determining the prognosis and optimal treatment of non-alcoholic steatohepatitis (NASH). In this study, we aimed to investigate the clinical usefulness of measuring the G/H ratio for predicting the severity of liver fibrosis in patients with NASH. The study subjects were 36 patients with histologically diagnosed NASH (19 men, 17 women; mean age 54.8±12.2 years, body mass index 28.3±5.0 kg/m2). The relationships of the G/H ratio to hepatic function tests and fibrosis stage in the liver were investigated. The G/H ratio in patients with NASH was inversely correlated with ALT (P<0.001) and platelet count (P<0.0001). Furthermore, the G/H ratio was positively correlated with the fibrosis stage in liver (P=0.003). These results suggest that the G/H ratio increases along with the fibrosis stage in patients with NASH.