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Some oral antidiabetic medications may prevent Type 2 diabetes in people at high risk for it, but the evidence is insufficient to determine whether the potential benefits outweigh the possible risks

Some oral antidiabetic medications may prevent Type 2 diabetes in people at high risk for it, but the evidence is insufficient to determine whether the potential benefits outweigh the possible risks

Evidence-Based Medicine 17(4): 111-112

Type 2 diabetes has its origins in obesity-associated insulin resistance compounded by a progressive inability to secrete adequate amounts of insulin in compensation. Clinical trials have shown that non-pharmacological strategies can reduce the risk of progression of glucose intolerance to diabetes in obese glucose-intolerant individuals. All too often however, clinical practice exposes the difficulties that many people have in achieving and sustaining lifestyle changes. Alternative strategies for diabetes prevention have therefore been sought. Methods In this meta-analysis, Phung et al identified randomised controlled studies (placebo or active comparator) of at least 3 months duration that each enrolled at least 2 participants. In addition to a conventional meta-analysis, the authors performed a mixed-treatment comparison. The aim of the latter analysis was to determine the comparative efficacy of three classes of oral glucose-lowering drugs via indirect between-trial comparisons. A number of prespecified subgroup sensitivity analyses were also.

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Accession: 036509817

Download citation: RISBibTeXText

PMID: 22193564

DOI: 10.1136/ebmed-2011-100332

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