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Incident diabetes and statins: the blemish of an undisputed heavy weight champion?



Incident diabetes and statins: the blemish of an undisputed heavy weight champion?



British Journal of Clinical Pharmacology 75(4): 955-958



Statins constitute important pharmacologic agents for reduction of cardiovascular (CV) risk. However, analyses of cumulative clinical studies have led to the realization that extended statin use increases the risk of incident diabetes, albeit modestly. Nevertheless, statins represent the strongest CV risk reduction tool in diabetics and non-diabetics, thus there is no justification for withholding statins to avoid excess risk of diabetes. However, concerted efforts could be made to balance the benefits versus risks of statin therapy. As a general approach, monitoring blood sugar during statin therapy is reasonable. However, the tailored use of statins would be aided by an understanding of the underlying mechanisms for statin-induced dysregulation of glucose metabolism. Similarly, improved knowledge of the clinical or biochemical predictors of incident diabetes during extended use of statins will facilitate patient care.

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Accession: 036553477

Download citation: RISBibTeXText

PMID: 22924471

DOI: 10.1111/j.1365-2125.2012.04445.x


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