+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Contrast media-doped hydrodissection during thermal ablation: optimizing contrast media concentration for improved visibility on CT images



Contrast media-doped hydrodissection during thermal ablation: optimizing contrast media concentration for improved visibility on CT images



Ajr. American Journal of Roentgenology 199(3): 677-682



The purpose of this study is to determine a concentration of iodinated contrast media in saline and 5% dextrose in water (D5W) for organ hydrodissection, a technique used to physically separate and protect tissues adjacent to thermal ablations. A total of 28 samples were prepared from 1:1000-1:1 iohexol or iothalamate meglumine contrast media in either normal saline or D5W. Samples alone or juxtaposed with a homogeneous liver-mimicking phantom were imaged by CT using 80-120 kVp and 10-300 mAs. Mean CT numbers and noise were measured from the fluid, background air, phantom adjacent to the fluid, and phantom distant from the fluid. Visibility was determined from the contrast-to-noise ratio between the fluid and phantom, whereas streaking artifact was quantified by relative noise in the phantom. Measures were individually fit using multiple linear regression to determine an optimal contrast-to-fluid ratio for increased visualization without streaking. Contrast media- and blood-doped saline and D5W were also tested to determine whether such doping altered their electrical conductivity. Iohexol concentration most influenced CT number; volumetric ratios of 1:1000-1:1 produced 20 HU to over 3000 HU. CT numbers were weakly dependent on x-ray tube voltage, whereas contrast-to-noise ratio and streaking artifacts were somewhat dependent on tube output. An optimal ratio of iohexol in fluid was determined to be 1:50. There was no significant difference between the electrical impedances of doped and pure saline or D5W (p > 0.5, all cases). A 1:50 ratio of iohexol in saline or D5W provides an optimal combination of increased visibility on CT without streaking artifacts.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036553689

Download citation: RISBibTeXText

PMID: 22915411

DOI: 10.2214/ajr.11.7999


Related references

Improved contrast enhancement with a positive pressure drip infusion method and 350 mg I/ml high concentration contrast media in routine contrast enhanced CT. Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica 49(1): 35-41, 1989

Improved contrast enhancement with positive pressure drip infusion method and 350 mg iodine per ml high concentration contrast media on routine contrast enhanced ct. Nippon Acta Radiologica 49(1): 35-41, 1989

Contrast media and metformin: guidelines to diminish the risk of lactic acidosis in non-insulin-dependent diabetics after administration of contrast media. ESUR Contrast Media Safety Committee. European Radiology 9(4): 738-740, 1999

Studies on serum contrast media concentration in angiography using I-131 labeled contrast media. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 114(1): 74-84, 1971

Recommendations of the European Society of Urogenital Radiology on the use of contrast media and the opportunity to use paramagnetic contrast in patients allergic to iodinated contrast media treated with endourology. Actas Urologicas Espanolas 26(10): 820, 2003

Selection of contrast medium for CT: what percentage of patients receiving CT needs nonionic contrast media (low-osmolarity contrast media)?. Academic Radiology 5(Suppl. 1): S49, 1998

Systemic and local reactions in leg phlebography with special reference to iodine-containing contrast media. Randomized, prospective, intraindividual double-blind study using iodine-containing contrast media of different osmolarity and iodine concentration. I. Der Radiologe 24(1): 46-50, 1984

A fundamental chemicophysical and radiographic study of the barium sulfate contrast media for G.I. examination. I. A chemicophysical evaluation of the conventionally available barium sulfates. II. An attempt to incorporate improved contrast media. Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica 30(3): 237-257, 1970

Nuclear magnetic resonance tomography: better images with contrast media. Contrast caused by paramagnetic properties--also imaging of the abdomen. Fortschritte der Medizin 106(27): 74-75, 1988

Improved identification of details in double-contrast studies of the stomach using a new mixture of contrast media. Rontgen-Blatter; Zeitschrift für Rontgen-Technik und Medizinisch-Wissenschaftliche Photographie 37(1): 13-15, 1984

Plasma osmolality iodine concentration and urographic images following high and low osmolar contrast media. Clinical Radiology 43(5): 331-336, 1991

Effect of iodine concentration of contrast media on contrast enhancement in multislice CT of the pancreas. British Journal of Radiology 77(922): 821-830, 2004

Computed tomography contrast enhancement principles and the use of high-concentration contrast media. Journal of Computer Assisted Tomography 28(Suppl. 1): S7, 2004

Contrast media in magnetic resonance tomography. A review. 1. Physicochemical and pharmacological bases of MR contrast media using gadolinium-DTPA as an example. Rofo 142(6): 641-646, 1985

Comparison of arthrography with a non-ionic dimeric contrast media with arthroscopy and the surgical result in patients with hypersensitivity to contrast media. Wiener Medizinische Wochenschrift 139(10): 235-237, 1989