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Chromatin-linked determinants of zygotic genome activation



Chromatin-linked determinants of zygotic genome activation



Cellular and Molecular Life Sciences 70(8): 1425-1437



The merging of the maternal and paternal genomes into a single pronucleus after fertilization is accompanied by a remarkable reconfiguration of chromatin in the newly formed zygote. The first stages of embryonic chromatin remodeling take place in the absence of ongoing transcription, during a species-specific developmental time-frame. Once post-fertilization chromatin states are organized, zygotic genome activation (ZGA) is initiated, and embryonic transcripts gradually take control of development. We review here transitions in chromatin modifications associated with the onset of ZGA, and the role of transcription factors and DNA motifs in the regulation of ZGA. We propose a model of sequential chromatin remodeling events preceding ZGA, leading to the onset of embryonic transcription.

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Accession: 036579489

Download citation: RISBibTeXText

PMID: 22965566

DOI: 10.1007/s00018-012-1143-x


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