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Chromatin-linked determinants of zygotic genome activation

Chromatin-linked determinants of zygotic genome activation

Cellular and Molecular Life Sciences 70(8): 1425-1437

The merging of the maternal and paternal genomes into a single pronucleus after fertilization is accompanied by a remarkable reconfiguration of chromatin in the newly formed zygote. The first stages of embryonic chromatin remodeling take place in the absence of ongoing transcription, during a species-specific developmental time-frame. Once post-fertilization chromatin states are organized, zygotic genome activation (ZGA) is initiated, and embryonic transcripts gradually take control of development. We review here transitions in chromatin modifications associated with the onset of ZGA, and the role of transcription factors and DNA motifs in the regulation of ZGA. We propose a model of sequential chromatin remodeling events preceding ZGA, leading to the onset of embryonic transcription.

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Accession: 036579489

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PMID: 22965566

DOI: 10.1007/s00018-012-1143-x

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