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Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging

, : Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. BMC Neurology 12(1)

This article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer's disease. Few cases have so far described bilateral hippocampal atrophy mimicking Alzheimer's disease in neurosyphilis.Case presentationThe patient presented here is a 33 year old Bulgarian male, whose clinical features include progressive cognitive decline and behavioral changes over the last 18 months. Neuropsychological examination revealed mild to moderate dementia (Mini Mental State Examination score was 16/30) with impaired memory and attention, and executive dysfunction. Pyramidal, and extrapyramidal signs, as well as dysarthria and impairment in coordination, were documented. Brain magnetic resonance imaging showed cortical atrophy with noticeable bilateral hippocampal atrophy. The diagnosis of active neurosyphilis was based on positive results of the Venereal Disease Research Laboratory test/Treponema pallidum hemagglutination reactions in blood and cerebrospinal fluid samples. In addition, cerebrospinal fluid analysis showed pleocytosis and elevated protein levels. High-dose intravenous penicillin therapy was administered. At 6 month follow up, improvements were noted clinically, on neuropsychological examinations, and in cerebrospinal fluid samples.This case underlines the importance of early diagnosis of neurosyphilis. The results suggest that neurosyphilis should be considered when magnetic resonance imaging results indicate mesiotemporal abnormalities and hippocampal atrophy. Neurosyphilis is a treatable condition which requires early aggressive antibiotic therapy.

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Nguyen, Phuong N.; Young, I. Ross.; Walker, David W.; Hirst, Jonathan J., 2004: Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep. Neuroactive steroids may be synthesised in the brain either de novo from cholesterol or from blood-borne precursors. Concentrations of a GABA, receptor agonist, allopregnanolone, in the fetal brain exceed those in the circulation, and are markedly...

Bergmann, T.; Richardson, Tl; Paerl, Hw; Pinckney, Jl; Schofield, O., 2002: Synergy of light and nutrients on the photosynthetic efficiency of phytoplankton populations from the Neuse River Estuary, North Carolina. A series of mesocosm studies were conducted using natural phytoplankton communities isolated from the Neuse River Estuary in the spring of 1998 and 1999 to assess the interactions between nutrient limitation and ultraviolet (UV) radiation on photo...

Liu, Zizhen; Bilston, Lynne, E., 2002: Large deformation shear properties of liver tissue. Characterization of the mechanical properties of soft biological tissues is important for establishing the mechanical tolerances of the tissues, and for input to computational models. In this work, the viscoelastic properties of bovine liver tissu...

Kis, L., 1977: Economical Research Institute for the Food Industries is 15 years old. Elelmezesi ipar: 1 (2) 43-48

Brightman, I.; Macha, H. N.; Von Zwehl, D.; Reichle, G.; Kunze, W.P., 1993: Sequential BAL, histology and clinical parameters in exogen allergic alveolitis. Pathology Research & Practice 189(6-7): 658-659

Kotin, Paul; Falk, Hans L.; Mccammon, Charles J., 1958: The experimental induction of pulmonary tumors and changes in the respiratory epithelium In C57 Bl mice following their exposure to an atmosphere of ozonized gasoline. C57 Bl mice exposed to an atmosphere of ozonized gasoline responded with the production of a significant number of pulmonary tumors when compared with control mice maintained in a washed air chamber. The test mice additionally showed marked hyperp...

Kingwell B.; Mckenna M.J.; Sandstrom E.R.; Hargreaves M., 1989: Effect of glucose polymer ingestion on energy and fluid balance during exercise. Nine male triathletes were studied during 160 min of exercise at 65% .ovrhdot.VO2 max on two occasions to examine the effect of glucose polymer ingestion on energy and fluid balance. During one trial they received 200 ml of a 10% glucose polymer s...

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Misra, K. K.; Jaiswal, H. R., 1992: A note on the effect of growth regulators on rooting, root characteristics and survival of air layers of Natal plum (Carissa grandiflora DC). IBA and NAA, each at 2500-10 000 p.p.m., were applied to 2-year-old lateral shoots of C. grandiflora [C. macrocarpa] for air-layering. Layering was carried out in the last week of Aug. and rooted layers were severed from mother plants 60 days late...