EurekaMag.com logo
+ Translate

Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging


, : Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging. BMC Neurology 12(1)

This article reports a rare case of active neurosyphilis in a man with mild to moderate dementia and marked hippocampal atrophy, mimicking early onset Alzheimer's disease. Few cases have so far described bilateral hippocampal atrophy mimicking Alzheimer's disease in neurosyphilis.Case presentationThe patient presented here is a 33 year old Bulgarian male, whose clinical features include progressive cognitive decline and behavioral changes over the last 18 months. Neuropsychological examination revealed mild to moderate dementia (Mini Mental State Examination score was 16/30) with impaired memory and attention, and executive dysfunction. Pyramidal, and extrapyramidal signs, as well as dysarthria and impairment in coordination, were documented. Brain magnetic resonance imaging showed cortical atrophy with noticeable bilateral hippocampal atrophy. The diagnosis of active neurosyphilis was based on positive results of the Venereal Disease Research Laboratory test/Treponema pallidum hemagglutination reactions in blood and cerebrospinal fluid samples. In addition, cerebrospinal fluid analysis showed pleocytosis and elevated protein levels. High-dose intravenous penicillin therapy was administered. At 6 month follow up, improvements were noted clinically, on neuropsychological examinations, and in cerebrospinal fluid samples.This case underlines the importance of early diagnosis of neurosyphilis. The results suggest that neurosyphilis should be considered when magnetic resonance imaging results indicate mesiotemporal abnormalities and hippocampal atrophy. Neurosyphilis is a treatable condition which requires early aggressive antibiotic therapy.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 036586444

PMID: 22994551

DOI: 10.1186/1471-2377-12-96

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Bokil, M. S., 2002: Tribal communities and sustainable livelihoods: lessons from Bordi. The important issue before the tribal communities in India today is how to earn and sustain livelihoods. The issue has become critical because access to and control over the surrounding natural resources have been endangered. It is therefore neces...

Chen, Gui-ying; Li, Wei; Liu, Jiong-yu; Zheng, Zhong-hua; Xie, Feng, 2008: A skeletochronological method for amphibians. Sichuan Journal of Zoology 27.2 (March 30): 227-229

Wada, Seiki; Kurihara, Susumu; Imamaki, Keiji; Yokota, Keisuke; Kitahama, Shinji; Yamanaka, Kayo; Itabashi, Akira; IItaka, Makoto; Katayama, Shigehiro, 1999: Hypercalcemia accompanied by hypothalamic hypopituitarism, central diabetes inspidus and hyperthyroidism. We present here a case of prominent hypercalcemia accompanied by hypothalamic tumor and Graves' disease. A 24-year-old man with hypothalamic tumor showed hypopituitarism, central diabetes inspidus (DI) and hyperthyroidism. Nausea, loss of thi...

Lengfelder, E.; Reichert, A.; Hehlmann, R.; Loeffler, H.; Fonatsch, C.; Schoch, C.; Staib, P.; Seifarth, W.; Sauerland, M. C.; Heinecke, A.; Woermann, B.; Hiddemann, W.; Buechner, T., 1997: Effects of high dose cytarabin as part of double induction strategy in acute promyelocytic leukemia and results of combination with all trans retinoic acid. Blood 90(10 SUPPL 1 PART 1): 330A, Nov 15

CHUANG, Fei-Chi; HUANG, Kuan-Hui; KUO, Hann-Chorng, 2013: Lower Urinary Tract Symptoms and Video-Urodynamic Characteristics of Women with Clinically Unsuspected Bladder Outlet Obstruction. To analyze the lower urinary tract symptoms (LUTS) and video-urodynamic characteristics of women with clinically unsuspected bladder outlet obstruction (BOO).From 1997 to 21, a total of 165 women with bothersome LUTS received video-urodynamic stud...

Addison, David S.; Ritchie, Scott A., 1993: Cattle fatalities from prolonged exposure to Aedes taeniorhynchus in southwest Florida. On 25 July 1988 a veterinary autopsy attributed the deaths of 3 cattle to prolonged exposure to mass feeding by mosquitoes. During the winter and spring of 1988 an unseasonal delay in the rainy season in coastal mangrove areas resulted in high pop...

Khokhryakov A.P.; Mazurenko M.T., 1989: Five new taxa from the caucasus ussr. Byulleten' Moskovskogo Obshchestva Ispytatelei Prirody Otdel Biologicheskii 94(6): 95-99

Smith G.W.; Hannan S.F.; Scott P.J.; Simpson I.J., 1982: Immune complex like activity associated with abnormal serum lipo proteins in systemic lupus erythematosus. Sera from 4 patients with systemic lupus erythematous (SLE) contained abnormal lipoproteins which behaved as immune complexes (IC). One IC lipoprotein (IC very low density lipoprotein [VLDL]) had the density in ultracentrifugation of VLDL, but a m...

Haynes, Kf, 1990: Identification of sex pheromone of bristly cutworm, Lacinipolia reingera (Stephens). The sex pheromone of the bristly cutworm moth, Lacinipolia renigera was identified as a blend of (Z)-9-tetradecenyl acetate (Z9-14: Ac) and (Z, E)-9,12-tetradecadienyl acetate (ZE-9,12-14: Ac). Extracts of female glands were analyzed by capillary...

Yuan, Zhigou; Vanrolleghem, Peter A.; Vansteenkiste, Ghislain C., 1997: Modeling error identification of activated sludge models. Information about the location of modeling errors is crucial for the efficient improvement of an invalid model. This article discusses how to pinpoint modeling errors through comparison of experimental data with data obtained through simulation of...