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Perineural granulomatous inflammation: a potential harbinger of perineural invasion in cutaneous squamous cell carcinoma



Perineural granulomatous inflammation: a potential harbinger of perineural invasion in cutaneous squamous cell carcinoma



British Journal of Dermatology 168(4): 899-901



Cutaneous squamous cell carcinoma (cSCC) is a cutaneous malignancy that is locally destructive and occasionally metastatic. There are previously described high-risk features of aggressive cSCCs including large size (>2 cm), thick or deeply invasive tumors (>4-5 mm), incomplete excision, recurrence, poorly-differentiated histology, presence of perineural invasion, location on or near mucosal surfaces and occurrence in an immunosuppressed host which are associated with an increased risk of metastatic disease. 1?3 Although not a recognized risk factor, some authorities believe that perineural lymphocytic inflammation can mask adjacent perineural invasion. 4.

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Accession: 036632309

Download citation: RISBibTeXText

PMID: 23106434

DOI: 10.1111/bjd.12102


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