+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in circadian time structure of diastolic blood pressure between diabetes mellitus and essential hypertension

Diabetology & Metabolic Syndrome 4(1): 51-51
Differences in circadian time structure of diastolic blood pressure between diabetes mellitus and essential hypertension
Abnormal circadian blood pressure patterns have been associated with cardiovascular disease in diabetes mellitus. We have described that the acrophase of diastolic blood pressure (DBP) registered in type 1 diabetes (T1D) patients was significantly earlier than normal and DBP ecphasia was more pronounced in patients with lower heart rate variability during deep breathing. The aim of this study was to compare the circadian rhythm characteristics of BP among different groups: normotensive (NT) control subjects, patients affected by T1D and type 2 diabetes (T2D), and patients with essential hypertension (HT).FindingsWe retrospectively evaluated ambulatory blood pressure monitoring records in 30 NT, 20 T1D, 20 T2D, 20 HT whose fasting plasma glucose and HbA1c were contemporaneously measured. The four groups were well-matched regarding age, gender, and BMI.Systolic blood pressure (SBP) and DBP midline-estimating statistic of rhythm were higher in T1D, T2D, and HT groups. DBP ecphasia was present only in the diabetic individuals: the acrophase of DBP occurred four hours earlier than normal in T1D group, whereas two hours earlier in T2D group. In a multiple regression analysis, only HbA1c and SBP acrophase were statistically significant correlates of DBP acrophase. People with diabetes mellitus, both type 1 and type 2, have their circadian acrophase of DBP occurring 2--4 hours earlier than normotensive and hypertensive subjects. Altered circadian timing of DBP, potential trigger of cardiovascular events, seems to be a distinguishing feature of diabetes mellitus and correlates with the previous 2--3 months of glycaemic control.

(PDF same-day service: $19.90)

Accession: 036655791

PMID: 23245213

DOI: 10.1186/1758-5996-4-51

Related references

Circadian variations of blood pressure and heart rate in essential hypertension with or without diabetes mellitus. European Heart Journal 15(ABSTR SUPPL ): 599, 1994

Left ventricular diastolic function and circadian variation of blood pressure in essential hypertension. Texas Heart Institute Journal 32(1): 28-34, 2005

Circadian variations of blood pressure and pulse rate in essential hypertensives with diabetes mellitus. Clinical and Experimental Pharmacology & Physiology 20(3): 155-160, 1993

Circadian rhythm of blood pressure and heart rate in hypertension with type 2 diabetes mellitus. Kardiologia Polska 39(7): 23-26, 1993

Circadian rhythm of blood pressure in adolescents with hypertension and insulin dependent diabetes mellitus. Pediatria Polska 71(5): 417-422, 1996

Effects of postprandial blood pressure and pulse pressure on carotid remodeling and atherosclerosis in essential hypertension and diabetes mellitus. American Journal of Hypertension 16(5 Part 2): 232A, May, 2003

The effect of melatonin on circadian blood pressure in patients with type 2 diabetes and essential hypertension. Archives of Medical Science 10(4): 669-675, 2014

The relation between the period and height of diastolic blood pressure in essential hypertension and glomerulonephitis Possible importance of renal factors for essential hypertension. 1959

Relationship between metabolic syndrome, circadian treatment time, and blood pressure non-dipping profile in essential hypertension. Chronobiology International 28(6): 509-519, 2011

The relation between the length of the period and the height of the diastolic blood pressure in essential hypertension and glomerulonephritis; possible significance of renal factors in essential hypertension. Cardiologia 35: 92-109, 1959