+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma



Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma



Diseases of the Esophagus 26(6): 636-643



Centromere protein F (CENP-F), a cell cycle-regulated centromere protein, has been shown to affect numerous tumorigenic processes. This study aimed to clarify the prognostic significance of CENP-F expression in patients with esophageal squamous cell carcinoma (ESCC). The levels of CENP-F messenger RNA and protein were higher in ESCC cell lines than in the normal tissues. An immunohistochemical analysis of paired tissue specimens showed that the CENP-F expression was higher in tumorous tissues than in the adjacent non-tumorous tissues (P < 0.001). Moreover, there was a significant correlation between CENP-F expression and gender (P = 0.012), clinical stage (P = 0.039), and T classification (P = 0.026). Patients with higher CENP-F expression had shorter overall survival than those with lower CENP-F expression (P = 0.009). Multivariate Cox analysis indicated that CENP-F expression is an independent prognostic factor for overall survival (hazard ratio = 0.582, 95% confidence interval = 0.397-0.804, P = 0.041). Importantly, it was found that zoledronic acid (ZOL) could significantly enhance the chemotherapeutic sensitivity of ESCC cell lines with high CENP-F expression to cisplatin, although ZOL alone only exhibited a minor inhibitory effect to ESCC cells. In summary, these findings demonstrate that CENP-F may serve as a valuable molecular marker for predicting the prognosis of ESCC patients. In addition, the data indicate a potential benefit of combining ZOL with cisplatin in ESCC, suggesting that CENP-F expression may have therapeutic implications.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036682553

Download citation: RISBibTeXText

PMID: 23163484

DOI: 10.1111/dote.12002


Related references

Prognostic relevance of Centromere protein H expression in esophageal carcinoma. Bmc Cancer 8: 233, 2008

Prognostic relevance of Id-1 expression in patients with resectable esophageal squamous cell carcinoma. Annals of Thoracic Surgery 93(5): 1682-1688, 2012

Reduced expression of p63 has prognostic implications for patients with esophageal squamous cell carcinoma. Oncology Reports 15(2): 323-328, 2006

Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma. Oncotargets and Therapy 12: 1917-1927, 2019

Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma. Bmc Cancer 10: 467, 2010

Expression and prognostic relevance of Id1 in stage III esophageal squamous cell carcinoma. Cancer Biomarkers 8(2): 67-72, 2011

Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Molecular Cancer 9: 237, 2010

Expression and prognostic relevance of p21WAF1 in stage III esophageal squamous cell carcinoma. Diseases of the Esophagus 25(1): 67-71, 2012

Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma. World Journal of Gastroenterology 16(41): 5195-5202, 2010

Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma. International Journal of Cancer 110(2): 201-207, 2004

Expression and prognostic relevance of cyclophilin A and matrix metalloproteinase 9 in esophageal squamous cell carcinoma. Diagnostic Pathology 8: 207, 2013

Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma. Cancer 94(7): 1955-1960, 2002

T-cell immunoglobulin and mucin domain-containing protein-3 and galectin-9 protein expression: Potential prognostic significance in esophageal squamous cell carcinoma for Chinese patients. Oncology Letters 14(6): 8007-8013, 2017

PIK3CA gene mutations and overexpression: implications for prognostic biomarker and therapeutic target in Chinese esophageal squamous cell carcinoma. Plos one 9(7): E103021, 2014

Expression of carbohydrate antigens in human esophageal squamous cell carcinoma: prognostic application and its diagnostic implications. Annals of Surgical Oncology 14(2): 960-967, 2007