EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes



The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes



Journal of Diabetes and Its Complications 27(2): 141-149



We determined the association between novel and acid-labile skin collagen-linked advanced glycation endproducts (AGEs) and the progression of microvascular and neuropathic complications from baseline to near study closeout in the Diabetes Control and Complications Trial (DCCT). From a skin biopsy obtained near the close of the DCCT, proteolytic collagen digests were analyzed by liquid chromatography/mass spectrometry (LC/MS/MS) for glucosepane (GSPNE), glyoxal and methylglyoxal hydroimidazolones (G-H1 and MG-H1) and the glycation product fructose-lysine (FL) using isotope dilution method. GSPNE and MG-H1 correlated with age and diabetes duration (P<0.02), while GSPNE and FL correlated with the history of glycemia expressed as mean A1c (P?0.003). Age and duration-adjusted GSPNE and FL levels were lower in intensive (INT) vs. conventional (CONV) treatment subjects in the primary prevention DCCT cohort (P<0.0001), and FL was lower in INT in the secondary intervention cohort (P<0.0001). GSPNE was associated with increased incidence of retinopathy progression (odds ratio (OR) / unit increase in GSPNE: 2.5 for 3 step progression on the ETDRS scale, P=0.003) and sustained?3 microaneurysms (MA) (OR=4.8, P<0.0001) from DCCT baseline up to the time of the biopsy, and prevalence of microalbuminuria or AER>40mg/24h (OR=5.3, P<0.0001), and confirmed clinical neuropathy (OR=3.4, P=0.015) at the time of the biopsy. GSPNE adjusted for mean A1c remained significant for ?3 MA (P=0.0252) and AER (P=0.0006). The strong association of complications with A1c was reduced or eliminated when adjusted for GSPNE. Glucosepane is a novel AGE marker of diabetic complications that is robustly associated with nephropathic, retinopathic and neuropathic outcomes despite adjustment for A1c, suggesting that it could be one mediator of these complications with possible diagnostic implications.

(PDF emailed within 0-6 h: $19.90)

Accession: 036697910

Download citation: RISBibTeXText

PMID: 23153673

DOI: 10.1016/j.jdiacomp.2012.10.004



Related references

Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes. Diabetes 64(1): 266-278, 2015

Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes. Diabetes 54(11): 3103-3111, 2005

Glucosepane and oxidative markers in skin collagen correlate with intima media thickness and arterial stiffness in long-term type 1 diabetes. Journal of Diabetes and Its Complications 29(3): 407-412, 2016

Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial. Diabetes 48(4): 870-880, 1999

The role of endothelial dysfunction driven by adipocitokines in the development and progression of microvascular complications in patients with type 1 and type 2 diabetes. Medical Hypotheses 84(6): 593-595, 2016

Association of low educational status with microvascular complications in type 2 diabetes: Jaipur diabetes registry. Indian Journal of Endocrinology and Metabolism 19(6): 775-780, 2015

Association of low educational status with microvascular complications in type 2 diabetes: Jaipur diabetes registry-1. Indian Journal of Endocrinology and Metabolism 19(5): 667-672, 2015

Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocrine Journal 53(4): 503-510, 2006

Evaluation of risk factors for the progression of diabetic microvascular complications in patients with type 2 diabetes mellitus. Medical Journal of Hiroshima University 48(1): 73-84, 2000

Nocturnal blood pressure is associated with the progression of microvascular complications and hypertension in patients with type 1 diabetes mellitus. Journal of Diabetes and Its Complications 30(7): 1326-1332, 2016

Modern views of causes of microvascular complications development and progression in type 2 diabetes mellitus and peculiarities of their treatment. Vestnik Oftalmologii 129(4): 70-75, 2013

Effect of glycemic treatment and microvascular complications on menopause in women with type 1 diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort. Diabetes Care 37(3): 701-708, 2015

Retinal vascular geometry and its association to microvascular complications in patients with type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). Graefe's Archive for Clinical and Experimental Ophthalmology, 2016

The association between bone turnover markers and microvascular complications of type 2 diabetes. Journal of Diabetes and Metabolic Disorders 15(): 51-51, 2016

Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes. Cardiovascular Diabetology 15(): 30-30, 2016