+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Quantitative 3-T diffusion tensor imaging in detecting optic nerve degeneration in patients with glaucoma: association with retinal nerve fiber layer thickness and clinical severity



Quantitative 3-T diffusion tensor imaging in detecting optic nerve degeneration in patients with glaucoma: association with retinal nerve fiber layer thickness and clinical severity



Neuroradiology 55(4): 493-498



To investigate the association of quantitative 3-T diffusion tensor imaging (DTI) with retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and clinical severity in detecting optic nerve degeneration in patients with primary closed-angle glaucoma. Twenty three patients (42 eyes; 9 men, 14 women) with primary closed-angle glaucoma and 20 healthy controls were enrolled in this study. Both DTI and OCT were performed on the optic nerves of all subjects. The mean diffusivity (MD), fractional anisotropy (FA), and eigenvalue maps were obtained for quantitative analysis. RNFL thickness and quantitative electrophysiology were also performed on all subjects. The association of quantitative DTI with RNFL thickness and glaucoma stage was analyzed. Compared with control nerves, the FA, λ[parallel], and λ[perpendicular] values, and RNFL thickness in affected nerves decreased, while MD increased in patients with primary glaucoma (p < 0.05). There was a significant correlation between FA, MD, λ[parallel], and λ[perpendicular] and the mean RNFL thickness (P < 0.01). The mean FA and λ[perpendicular] values derived with DT MR imaging correlated well with glaucoma stage (P < 0.05), but the mean MD and λ[parallel] values did not correlate with glaucoma stage (P > 0.05). DTI measurement could detect abnormality of the optic nerve in patients with glaucoma and may serve as a biomarker of disease severity.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036745276

Download citation: RISBibTeXText

PMID: 23358877

DOI: 10.1007/s00234-013-1133-1


Related references

Detecting optic nerve head deformation and retinal nerve fiber layer thinning in glaucoma progression. Taiwan Journal of Ophthalmology 5(2): 50-55, 2015

Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma. Journal of Ophthalmology 2015: 186249, 2015

The relationship between retinal nerve fiber layer thickness and optic nerve head neuroretinal rim tissue in glaucoma. Investigative Ophthalmology and Visual Science 55(10): 6802-6816, 2014

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma. Journal of Ophthalmology 2017: 2340236, 2017

Optic nerve diffusion tensor imaging parameters and their correlation with optic disc topography and disease severity in adult glaucoma patients and controls. Journal of Glaucoma 23(8): 513-520, 2015

Reproducibility of RTVue retinal nerve fiber layer thickness and optic nerve head measurements in normal and glaucoma eyes. Chinese Medical Journal 123(14): 1898-1903, 2010

Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements. Investigative Ophthalmology and Visual Science 50(12): 5741-5748, 2009

Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis. Multiple Sclerosis International 2011: 289785, 2011

Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. American Journal of Ophthalmology 139(1): 44-55, 2005

Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma. Investigative Ophthalmology and Visual Science 57(9): Oct404-12, 2017

American Chinese glaucoma imaging study: a comparison of the optic disc and retinal nerve fiber layer in detecting glaucomatous damage. Investigative Ophthalmology & Visual Science 48(6): 2644-2652, 2007

Diagnostic power of optic disc morphology, peripapillary retinal nerve fiber layer thickness, and macular inner retinal layer thickness in glaucoma diagnosis with fourier-domain optical coherence tomography. Journal of Glaucoma 20(2): 87-94, 2011

Association of retinal nerve fibre layer thickness with quantitative magnetic resonance imaging data of the optic chiasm in pituitary adenoma patients. Journal of Clinical Neuroscience 50: 1-6, 2018

Imaging of the optic nerve and retinal nerve fiber layer: an essential part of glaucoma diagnosis and monitoring. Survey of Ophthalmology 59(4): 458-467, 2014

Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation. European Journal of Radiology 83(8): 1437-1441, 2015