+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial



Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial



Journal of Infectious Diseases 208(1): 40-49



 We assessed factors associated with antiretroviral therapy (ART) adherence, including specific ART medications.  The Strategies for Management of Antiretroviral Therapy study was an international antiretroviral therapy (ART) strategy trial that compared intermittent ART, using CD4(+) T-cell count as a guide, to continuous ART. Adherence during the 7 days before each visit was measured using self-report. We defined high adherence as self-report of taking "all" pills for each prescribed ART medication; all other reports were defined as suboptimal adherence. Factors associated with adherence were assessed using logistic regression with generalized estimating equations.  Participants reported suboptimal adherence at 6016 of 35 695 study visits (17%). Factors independently associated with suboptimal adherence were black race, protease inhibitor-containing regimens, greater pill burden, higher maximum number of doses per day, and smoking. Factors independently associated with higher adherence were older age, higher education, region of residence, episodic treatment, higher latest (at the time of adherence) CD4(+) T-cell count, and being prescribed concomitant drugs (ie, medications for comorbidities). Of specific drugs investigated, atazanavir, atazanavir/ritonavir, fosamprenavir, indinavir, indinavir/ritonavir, and lopinavir/ritonavir were associated with suboptimal adherence, and tenofovir disoproxil fumarate/emtricitabine was associated with higher adherence.  In this, the largest analysis of ART adherence to date, some protease inhibitor-containing regimens and regimens with >1 dose per day were associated with suboptimal adherence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036750342

Download citation: RISBibTeXText

PMID: 23204161

DOI: 10.1093/infdis/jis731


Related references

Factors associated with adherence amongst 5,295 people on antiretroviral therapy as part of an international trial. 2013

Factors influencing antiretroviral therapy adherence among HIV-infected people on antiretroviral therapy in Ili Kazakh Autonomous Prefecture. Zhonghua Yu Fang Yi Xue Za Zhi 51(2): 160-164, 2017

HIV treatment adherence and unprotected sex practices in people receiving antiretroviral therapy. Sexually Transmitted Infections 79(1): 59-61, 2003

Patterns of individual and population-level adherence to antiretroviral therapy and risk factors for poor adherence in the first year of the DART trial in Uganda and Zimbabwe. Journal of Acquired Immune Deficiency Syndromes 48(4): 468-475, 2008

Factors associated with complementary therapy use in people living with HIV/AIDS receiving antiretroviral therapy. Journal of Alternative and Complementary Medicine 9(5): 695-710, 2003

Factors Associated with Antiretroviral Therapy Adherence Among Transgender Women Receiving HIV Medical Care in the United States. Lgbt Health 4(3): 181-187, 2017

Factors affecting adherence to antiretroviral therapy in people living with HIV/AIDS. Journal of the Association of Nurses in Aids Care 14(4): 37-45, 2003

Psychosocial factors in adherence to antiretroviral therapy among HIV-positive people who use drugs. Health Psychology 35(3): 290-297, 2016

Correlates of non-adherence to antiretroviral therapy in a cohort of HIV-positive drug users receiving antiretroviral therapy in Hanoi, Vietnam. International Journal of Std and Aids 25(9): 662-668, 2014

Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. Aids Research and Human Retroviruses 26(6): 685-691, 2010

Adherence to antiretroviral therapy and its associated factors among people living with HIV/AIDS in Addis Ababa, Ethiopia. Ethiopian Medical Journal 50(4): 355-361, 2012

Factors Influencing Adherence to Antiretroviral Therapy among People Living with HIV in Coastal South India. Journal of the International Association of Providers of Aids Care 15(6): 529-533, 2016

Antiretroviral therapy adherence and its determinant factors among people living with HIV/AIDS: a case study in Iran. Bmc Research Notes 12(1): 162, 2019

Factors associated with adherence to Antiretroviral Therapy (ART) among adult people living with HIV and attending their clinical care, Eastern Ethiopia. Bmc International Health and Human Rights 15: 33, 2015

A pilot study of health beliefs and attitudes concerning measures of antiretroviral adherence among prisoners receiving directly observed antiretroviral therapy. Aids Patient Care and Stds 20(6): 408-417, 2006