EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Risk factors and outcomes of Candida krusei bloodstream infection: a matched, case-control study


Risk factors and outcomes of Candida krusei bloodstream infection: a matched, case-control study



Journal of Infection 66(3): 278-284



ISSN/ISBN: 0163-4453

PMID: 23174708

DOI: 10.1016/j.jinf.2012.11.002

To investigate the risk factors and outcomes associated with Candida krusei bloodstream. We performed a case control study of patients with C. krusei bloodstream infection at the University of Pennsylvania from 1982 to 2010. Controls were without candidemia, and matched to cases on duration of hospitalization and underlying disease. We enrolled 34 cases and 114 matched controls. Most subjects (62%) had hematologic malignancies. In the multivariate model, including a priori the duration of fluconazole use (OR 1.06; 95% CI 1.00, 1.11) and days of neutropenia (OR 1.01; 95% CI 0.98, 1.13), risk factors associated with C. krusei bloodstream infection were splenectomy (OR 11.66; 95% CI 1.04, 130.64), and exposure to antimicrobials with anaerobic activity (OR 5.74; 95% CI 1.76, 18.67). Outcomes of infected patients were poor. Only 32% of case patients survived to hospital discharge, compared to 89% of controls. For 48% death was attributed to C. krusei infection. C. krusei bloodstream infection occurs most commonly in neutropenic patients with hematologic malignancy. The association with prior fluconazole exposure is less marked than previously described. Splenectomy and the receipt of antimicrobials with anaerobic activity are significant risk factors. The outcome of infected patients remains poor, despite appropriate antifungal therapy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036755004

Download citation: RISBibTeXText

Related references

Immunomodulatory therapy, risk factors and outcomes of hospital-acquired bloodstream infection in patients with severe COVID-19 pneumonia: a Spanish case-control matched multicentre study (BACTCOVID). Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 27(11): 1685-1692, 2021

Risk factors for Candida parapsilosis bloodstream infection in a neonatal intensive care unit: a case-control study. Italian Journal of Pediatrics 43(1): 10, 2017

Prior antimicrobial therapy and risk for hospital-acquired Candida glabrata and Candida krusei fungemia: a case-case-control study. Antimicrobial Agents and ChemoTherapy 49(11): 4555-4560, 2005

Risk factors for bloodstream infections at a cancer center A matched case-control study. Journal of Hospital Infection 40(Suppl A): P6113, 1998

Risk factors, antimicrobial susceptibility pattern and patient outcomes of Pseudomonas aeruginosa infection: A matched case-control study. Journal of Infection and Public Health 14(1): 152-157, 2021

Candida catheter-related bloodstream infection in patients on home parenteral nutrition - Rates, risk factors, outcomes, and management. Clinical Nutrition Espen 31: 1-9, 2019

Prehospital delay is an important risk factor for mortality in community-acquired bloodstream infection (CA-BSI): a matched case-control study. Bmj Open 11(11): E052582, 2021

Bloodstream infection with Oligella ureolytica, Candida krusei, and Bacteroides species in a patient with AIDS. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 17(2): 290-291, 1993

Risk factors for noncatheter-related Candida bloodstream infections in intensive care units: A multicenter case-control study. Medical Mycology 57(6): 668-674, 2019

Experimental Infection by Candida krusei (Cast.) Berkhout Isolated from a Case of Corneal Ulcer and its Sensitivitiy to Antimycotics : Experimentelle Infektion mit einem Stamm von Candida krusei (Cast.) Berkhout, der aus einem Hornhautulcus isoliert wurde und seine Empfindlichkeit gegen Antimykotica. Mycoses 27(7): 355-360, 1984

Risk factors for bloodstream infection in patients at a Brazilian hemodialysis center: a case-control study. Bmc Infectious Diseases 15: 158, 2015

Epidemiology, risk factors, and prognosis of Candida parapsilosis bloodstream infections: case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003. Journal of Clinical Microbiology 44(5): 1681-1685, 2006

Pediatric Risk Factors for Candidemia Secondary to Candida glabrata and Candida krusei Species. Journal of the Pediatric Infectious Diseases Society 2(3): 263-266, 2013

Risk Factors of Candida parapsilosis Catheter-Related Bloodstream Infection. Frontiers in Public Health 9: 631865, 2021

Comparison of the clinical risk factors between Candida albicans and Candida non-albicans species for bloodstream infection. Journal of Antibiotics 67(4): 311-314, 2014