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Pilot study of H2 therapy in Parkinsons disease A randomized double-blind placebo-controlled trial



Pilot study of H2 therapy in Parkinsons disease A randomized double-blind placebo-controlled trial







Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H2) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H2-dissolved water (H2-water) reduced oxidative stress and improved Parkinson's features in model animals. In this a placebo-controlled, randomized, double-blind, parallel-group clinical pilot study, the authors assessed the efficacy of H2-water in Japanese patients with levodopa-medicated PD. Participants drank 1,000 mL/day of H2-water or pseudo water for 48 weeks. Total Unified Parkinson's Disease Rating Scale (UPDRS) scores in the H2-water group (n=9) improved (median, ?1.0; mean standard deviation, ?5.7 8.4), whereas UPDRS scores in the placebo group (n=8) worsened (median, 4.5; mean standard deviation, 4.1 9.2). Despite the minimal number of patients and the short duration of the trial, the difference was significant (P<0.05). The results indicated that drinking H2-water was safe and well tolerated, and a significant improvement in total UPDRS scores for patients in the H2-water group was demonstrated.

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Accession: 036761295

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DOI: 10.1002/mds.25375


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