+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The osseointegration behavior of titanium-zirconium implants in ovariectomized rabbits

Clinical Oral Implants Research 25(7): 819-825

The osseointegration behavior of titanium-zirconium implants in ovariectomized rabbits

The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium zirconium (TiZr) implants in ovariectomized (OVX) rabbits. Twelve ovariectomized New Zealand rabbits submitted to a hypocalcic diet and 12 sham-aged rabbits were used. After the bone mass loss induction period, TiZr or Ti implants both benefiting from a SLActive surface treatment were randomly inserted in the tibia and femur of each animal. The total of 24 rabbits were divided in four groups (n = 6): SHAM + Ti, OVX + Ti, SHAM + TiZr,OVX + TiZr. The animals were respectively sacrificed 3 and 6 weeks after dental implant placement. Six implants in each group at each time point were subjected to removal torque testing, and the remaining implants were prepared for histomorphometric analysis. At the end of the healing period, all implants were osseointegrated. The removal torque value of the SHAM-TiZr group was significantly higher than those of the SHAM-Ti group (P < 0.001). The removal torque of the OVX-Ti group was significantly lower than those of the OVX-TiZr group. All groups demonstrated an increase in the peak torque value after 6 weeks: 46.0 and 50.8 Ncm for the OVX and the SHAM animals, respectively, in the case where Ti implants were used. When TiZr implants were inserted, the values reached 60.7 and 76.2 Ncm with a similar group configuration. The BIC and the BA/TA analysis showed an increase between week 3 and 6 in the case of nonovariectomized animals. From week 3 to 6, the BIC went from 37.1 14.3 to 47.7 8.7 for the SHAM + Ti group and from 37.6 10.9 to 50.4 11 for the SHAM + TiZr group. The BIC values were not significantly different between groups. The parameters intended to be representative of the bone morphology (BIC & BATA) did not help to discriminate between Ti and TiZr which appeared to behave similarly in this experimental model. However, the removal torque values for the TiZr group were statistically higher than those of the Ti group in both the SHAM and the ovariectomized animals. That likely reflected an increased quality of bone around the TiZr implants.

Accession: 036778806

PMID: 23432001

DOI: 10.1111/clr.12141

Related references

Schwarz, F.; Mihatovic, I.; Golubovic, V.; Bradu, S.; Sager, M.; Becker, Jürgen., 2014: Impact of plaque accumulation on the osseointegration of titanium-zirconium alloy and titanium implants. A histological and immunohistochemical analysis. To evaluate the impact of plaque accumulation on osseointegration at surface enhanced modified hydrophilic titanium-zirconium (TiZr) alloy and titanium (Ti) implants. TiZr and Ti implants with a sand-blasted, acid etched, and chemically modified e...

Kulakov, O.B.; Doktorov, A.A.; D'iakova, S.V.; Denisov-Nikol'skiĭ, I.I.; Grötz, K.A., 2005: Experimental study of osseointegration of zirconium and titanium dental implants. In an experiment performed on pigs, methods of light and scanning electron microscopy were used to study the interaction of zirconium and titanium dental implants with bone 6 months following their insertion. Distinct features of integration of bo...

Hoerth, R.M.; Katunar, Mía.R.; Gomez Sanchez, A.; Orellano, J.C.; Ceré, S.M.; Wagermaier, W.; Ballarre, J., 2014: A comparative study of zirconium and titanium implants in rat: osseointegration and bone material quality. Permanent metal implants are widely used in human medical treatments and orthopedics, for example as hip joint replacements. They are commonly made of titanium alloys and beyond the optimization of this established material, it is also essential t...

Vidigal, G.Maciel.; Groisman, M.; Gregório, L.Henrique.; Soares,, 2010: Osseointegration of titanium alloy and HA-coated implants in healthy and ovariectomized animals: a histomorphometric study. The objective of the present study is to evaluate the response to dental implants in healthy and osteoporotic bone. Ten ovariectomized (OVX) New Zealand rabbits submitted to a hypocalcic diet and 10 sham-aged rabbits were used. All animals were su...

Yildiz, A.; Esen, E.; Kürkçü, M.; Damlar, I.; Dağlioğlu, K.; Akova, T., 2010: Effect of zoledronic acid on osseointegration of titanium implants: an experimental study in an ovariectomized rabbit model. Zoledronic acid (ZA), a new-generation intravenous bisphosphonate, exhibits the greatest affinity for bone mineral with the longest retention, thereby leading to its ability to be dosed at annual intervals in the treatment of osteoporosis. The pur...

Koo, S.; König, B.; Mizusaki, C.Ioshie.; Allegrini, Sérgio.; Yoshimoto, M.; Carbonari, M.José., 2004: Effects of alcohol consumption on osseointegration of titanium implants in rabbits. Alcohol consumption affects bone metabolism by impairing osteoblast proliferation and by increasing osteoclastic activity. The purpose of this study was to evaluate bone formation in alcohol-fed rabbits following the insertion of dental titanium i...

Smeets, R.; Schöllchen, M.; Gauer, T.; Aarabi, G.; Assaf, A.T.; Rendenbach, C.; Beck-Broichsitter, B.; Semmusch, J.; Sedlacik, J.; Heiland, M.; Fiehler, J.; Siemonsen, S., 2016: Artifacts in multimodal imaging of titanium, zirconium and binary titanium-zirconium alloy dental implants: an in vitro study. To analyze and evaluate imaging artifacts induced by zirconium, titanium and titanium-zirconium alloy dental implants. Zirconium, titanium and titanium-zirconium alloy implants were embedded in gelatin and MRI, CT and CBCT were performed. Standard...

Sancho-Puchades, M.; Hämmerle, C.H.F.; Benic, G.I., 2014: In vitro assessment of artifacts induced by titanium, titanium-zirconium and zirconium dioxide implants in cone-beam computed tomography. The aim of this study was to test whether or not the intensity of artifacts around implants in cone-beam computed tomography (CBCT) differs between titanium, titanium-zirconium and zirconium dioxide implants. Twenty models of a human mandible, eac...

Salou, Lëtitia.; Hoornaert, A.; Louarn, G.; Layrolle, P., 2015: Enhanced osseointegration of titanium implants with nanostructured surfaces: an experimental study in rabbits. Titanium and its alloys are commonly used for dental implants because of their good mechanical properties and biocompatibility. The surface properties of titanium implants are key factors for rapid and stable bone tissue integration. Micro-rough s...

Ma, Y.; Zhang, Z.; Liu, Y.; Li, H.; Wang, N.; Liu, W.; Li, W.; Jin, L.; Wang, J.; Chen, S., 2015: Nanotubes Functionalized with BMP2 Knuckle Peptide Improve the Osseointegration of Titanium Implants in Rabbits. To determine the effects of surface modification on implant osseointegration in vivo, we first immobilized polydopamine onto 70-nm diameter TiO2 nanotubes as an intermediate layer, and then conjugated a 21 amino acid peptide sequence (the so-calle...