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RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt



RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt



Journal of Signal Transduction 2012: 248759



Interactions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion structure integrity and are key players in regulating transduction of specific intracellular signals, which in turn regulate the organization of the cell microenvironment and, consequently, cell function. The RGD peptide-dependent integrins represent a key subgroup of ECM receptors involved in the maintenance of epithelial homeostasis. Here we review recent findings on RGD-dependent ECM-integrin interactions and their roles in human intestinal epithelial crypt cells.

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Accession: 036794307

Download citation: RISBibTeXText

PMID: 22988499

DOI: 10.1155/2012/248759


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