+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nutrition management of amyotrophic lateral sclerosis

Nutrition management of amyotrophic lateral sclerosis

Nutrition in Clinical Practice 28(3): 392-399

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease with high risk of malnutrition. Symptoms of dysphagia, depression, cognitive impairment, difficulty with self-feeding and meal preparation, hypermetabolism, anxiety, respiratory insufficiency, and fatigue with meals increase the risk of malnutrition. Malnutrition negatively affects prognosis and quality of life, making early and frequent nutrition assessment and intervention essential. Implementation of an adequate calorie diet, dietary texture modification, use of adaptive eating utensils, and placement of a feeding tube aid in preventing malnutrition. When nutrition status is compromised by dysphagia and weight loss (5%-10% of usual body weight) or body mass index <20 kg/m(2) without weight loss and when forced vital capacity is >50%, a percutaneous endoscopic gastrostomy placement is indicated. When forced vital capacity is <50%, a radiologically inserted gastrostomy is the preferred means of enteral placement due to lessened aspiration and respiratory risk. Parenteral nutrition (PN) is indicated only when enteral nutrition (EN) is contraindicated or impossible. This article reviews the background of ALS, nutrition implications and risk of malnutrition, treatment strategies to prevent malnutrition, the role of EN and PN, and feeding tube placement methods according to disease stage.

Accession: 036796303

Download citation: RISBibTeXText

PMID: 23466470

DOI: 10.1177/0884533613476554

Related references

Nutrition assessment and management in amyotrophic lateral sclerosis. Physical Medicine and Rehabilitation Clinics of North America 23(4): 751-771, 2012

Amyotrophic Lateral Sclerosis Regional Variants (Brachial Amyotrophic Diplegia, Leg Amyotrophic Diplegia, and Isolated Bulbar Amyotrophic Lateral Sclerosis). Neurologic Clinics 33(4): 775-785, 2015

Attempts to reproduce amyotrophic lateral sclerosis in laboratory animals by inoculation of Schu virus isolated from a patient with apparent amyotrophic lateral sclerosis. Journal of Neurology 220(1): 1-19, 1979

Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. Journal of Neuropathology and Experimental Neurology 66(11): 1037-1044, 2007

The amyotrophic lateral sclerosis functional rating scale predicts survival time in amyotrophic lateral sclerosis patients on invasive mechanical ventilation. Chest 132(1): 64-69, 2007

Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?. Archives of Neurology 63(8): 1139-1143, 2006

Amyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-Parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology. Journal of Clinical Pathology. Supplement 6: 132-140, 1972

Immunohistochemical localization of brain-derived neurotrophic factor in the human spinal cord Comparative study of amyotrophic lateral sclerosis and non-amyotrophic lateral sclerosis patients. Brain Pathology 7(4): 1123, 1997

Amyotrophic lateral sclerosis. Physiopathology and experimental models. Chemical neuroanatomy of the human spinal cord: applications to pathologic cases including amyotrophic lateral sclerosis. Revue Neurologique 144(11): 664-671, 1988

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain 134(Pt 5): 1293-1314, 2011

Temporal lobe pathology in amyotrophic lateral sclerosis. Do amyotrophic lateral sclerosis and Alzheimer's disease share a common etiological factor?. Clinical Neuropathology 12(2): 88-91, 1993

Immunohistochemical localization of brain-derived neurotrophic factor in the spinal cords of amyotrophic lateral sclerosis and non-amyotrophic lateral sclerosis patients. Journal of Neuropathology and Experimental Neurology 57(9): 822-830, 1998

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations. Neuropathology 29(6): 672-683, 2009

Quantitative natural history of amyotrophic lateral sclerosis early rapid linear loss of tongue isometric muscle strength in prebulbar amyotrophic lateral sclerosis patients. Annals of Neurology 28(2): 232, 1990

Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis. Annals of Neurology 74(5): 699-708, 2013