+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China



VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China



Neurobiology of Aging 34(6): 1709.E7-8



The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, the frequencies of these 2 mutations among Chinese PD patients are unknown. We examined these mutations in a large cohort consisting of 609 PD patients and 600 healthy control subjects from Southwest China. Our results suggest that the Asp620Asn mutation in VPS35 and the Arg1205His mutation in EIF4G1 do not play a role in PD in the Southwest China population. The novel Arg1205Cys mutation in EIF4G1 detected in the current study should be further studied among other Asian patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 036807054

Download citation: RISBibTeXText

PMID: 23261770

DOI: 10.1016/j.neurobiolaging.2012.11.003


Related references

Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy. Neurobiology of Aging 35(10): 2422.E1-2, 2015

VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians. Neurobiology of Aging 34(10): 2442.E1-3, 2014

EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa. Neurobiology of Aging 35(2): 445.E1-3, 2014

Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease. Neurology 80(11): 982-989, 2013

EIF4G1 Ala502Val and Arg1205His variants in Chinese patients with Parkinson disease. Neuroscience Letters 543: 69-71, 2013

The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease. Movement Disorders 27(6): 800-801, 2012

Linking the VPS35 and EIF4G1 pathways in Parkinson's disease. Neuron 85(1): 1-3, 2015

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron 85(1): 76-87, 2015

EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?. Neurobiology of Aging 33(9): 2233.E1-2233.E5, 2012

EIF4G1 mutations do not cause Parkinson's disease. Neurobiology of Aging 36(8): 2444.E1-4, 2016

Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease. Parkinsonism and Related Disorders 18(5): 638-640, 2012

Mutations in EIF4G1 are not a common cause of Parkinson's disease. European Journal of Neurology 20(4): E59, 2013

VPS35 mutations in Parkinson disease. American Journal of Human Genetics 89(1): 162-167, 2011

Translation initiator EIF4G1 mutations in familial Parkinson disease. American Journal of Human Genetics 89(3): 398-406, 2011

Contributions of VPS35 mutations to Parkinson's Disease. Neuroscience 2019, 2019