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Antimicrobial efficacy of liposome-encapsulated silver ions and tea tree oil against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans

Antimicrobial efficacy of liposome-encapsulated silver ions and tea tree oil against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans

The activity of alternative antimicrobial agents such as tea tree oil (O) and silver ions (Ag+) with multiple target sites impedes the development of antibacterial resistance and might be useful in improving the current treatment strategies for various chronic wound infections. In this study liposome encapsulated O, Ag+ and O plus Ag+ were added to suspension cultures of Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans). Treatment of these cultures using the agents in combination at sub-minimal lethal concentrations resulted in an enhanced loss of viability compared to treatment with individual agents. The effective concentration, elimination time (to the limit of detection, LOD) and fractional lethal concentration index (FLCI) of liposomal agents in combination were as follows:C. albicans: 0.05%v/vO:PVA30-70kDa:8.9x10-5%w/vAg+:PVA30-70kDa:2.0hrs, FLCI = 0.73 (indifferent),S. aureus: 0.05%v/vO:PVA30-70kDa:6.0x10-4%w/vAg+:PVA30-70kDa:1.5hrs, FLCI = 0.38 (synergistic),P. aeruginosa: 0.25%v/vO:PVA30-70kDa:3.2x10-4%w/vAg+:PVA30-70kDa:30mins, FLCI = 0.33 (synergistic).These results show the potential for improving antimicrobial efficacy by delivering lower effective concentrations of alternative agents, via controlled release systems. NB All values denoted as%w/vAg+ refer to the concentration of silver ions.This article is protected by copyright. All rights reserved.

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Accession: 036848476

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PMID: 23581401

DOI: 10.1111/lam.12082

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