+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cannabinoid receptor-2 immunoreactivity is associated with survival in squamous cell carcinoma of the head and neck



Cannabinoid receptor-2 immunoreactivity is associated with survival in squamous cell carcinoma of the head and neck



British Journal of Oral and Maxillofacial Surgery 51(7): 604-609



The prediction of progression of individual tumours, prognosis, and survival in squamous cell carcinoma (SCC) of the head and neck is difficult. Cannabinoid-1 (CB1) and cannabinoid-2 (CB2) receptor expression is related to survival in several types of cancer, and the aim of this study was to find out whether the expression of CB1 and CB2 receptors is associated with survival in primary SCC of the head and neck. We made immunohistochemical analyses of the cannabinoid receptors on tissue arrays from 240 patients with the disease. Receptor immunoreactivity was classified as none, weak, moderate, or strong staining. Overall survival and disease-specific survival were plotted using Kaplan-Meier survival curves. A multivariate Cox proportional hazard model was created with all the relevant clinical and pathological features. Strong immunoreactivity of the CB2 receptor was significantly associated with reduced disease-specific survival (p=0.007). Cox-proportional hazard ratio (HR) showed that CB2 receptor immunoreactivity contributed to the prediction of survival (HR 3.6, 95% CI 1.5-8.7, p=0.004). Depth of invasion (HR 2.2, 95% CI 1.2-4.2, p=0.01) and vascular invasion (HR 2.5, 95% CI 1.4-4.5, p=0.001) were also associated with survival.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036852855

Download citation: RISBibTeXText

PMID: 23601830

DOI: 10.1016/j.bjoms.2013.03.015


Related references

NF-κB participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck. Oncology Reports 25(2): 383-391, 2011

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma. Anticancer Research 36(10): 5499-5506, 2016

The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma. Experimental and Molecular Pathology 82(1): 53-57, 2007

EGF receptor co-activates NF-kappaB and AP-1 signaling pathways that promote survival and pro-angiogenic factor expression in head and neck squamous cell carcinoma. Proceedings of the American Association for Cancer Research Annual Meeting 42: 942, 2001

Clinicopathologic features and p53 immunoreactivity in squamous cell carcinoma of the head and neck in patients under 40. Modern Pathology 9(1): 103A, 1996

Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells. Oncology Reports 27(4): 1135-1141, 2012

Survey of the use of tests for human papilloma virus and epidermal growth factor receptor for squamous cell carcinoma of the head and neck in UK head and neck multidisciplinary teams. British Journal of Oral and Maxillofacial Surgery 50(2): 119-121, 2012

Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. British Journal of Oral and Maxillofacial Surgery 48(4): 291-296, 2010

A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines. 2013

Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma. International Journal of Radiation Oncology Biology Physics 81(2): 331-338, 2011

Survival patterns in squamous cell carcinoma of the head and neck: pain as an independent prognostic factor for survival. Journal of Pain 15(10): 1015-1022, 2014

Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database. Orl; Journal for Oto-Rhino-Laryngology and its Related Specialties 78(2): 61-69, 2016

T-lymphocytes and survival of head and neck squamous cell carcinoma. Archives of Otolaryngology 103(4): 223-227, 1977

Soft tissue deposits in neck dissections of patients with head and neck squamous cell carcinoma: prospective analysis of prevalence, survival, and its implications. Archives of Otolaryngology--Head and Neck Surgery 130(2): 157-160, 2004

Autologous lymphocytotoxicity against squamous cell carcinoma in head and neck. I. In vitro culture of squamous cell carcinoma in head and neck. Nihon Jibiinkoka Gakkai Kaiho 84(12): 1570-1578, 1981