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Nutritional status of patients with alcoholic cirrhosis undergoing liver transplantation Time-trends and impact on survival



Nutritional status of patients with alcoholic cirrhosis undergoing liver transplantation Time-trends and impact on survival







Alcoholic cirrhotics evaluated for liver transplantation are frequently malnourished or obese. We analyzed alcoholic cirrhotics undergoing transplantation to examine time-trends of nutrition/weight, transplant outcome, and effects of concomitant hepatitis C virus (HCV) and/or hepatocellular carcinoma (HCC). utrition and transplant outcomes were reviewed for alcoholic cirrhosis with/without HCV/HCC. Malnutrition was defined by subjective global assessment. Body mass index (BMI) classified obesity. 261 patients receiving transplants were separated (1988-2000, 2001-2006, and 2007-2011) to generate similar size cohorts. Mean BMI for the whole cohort was 28 6 with 68% classified as overweight/obese. Mean BMI did not vary amongst cohorts and was not affected by HCV/HCC. While prevalence of malnutrition did not vary amongst cohorts, it was lower in patients with HCV/HCC (P<0.01). 1-year graft/patient survival was 90% and not impacted by time period, HCV/HCC, or malnutrition after adjusting for demographics and MELD. Alcoholic cirrhotics undergoing transplantation are malnourished yet frequently overweight/obese. Amongst patients selected for transplantation, 1-year post-transplant graft/patient survival is excellent, have not changed over time, and do not vary by nutrition/BMI. Our findings support feasibility of liver transplantation for alcoholic cirrhotics with obesity and malnutrition.This article is protected by copyright. All rights reserved.

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Accession: 036877214

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DOI: 10.1111/tri.12123


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