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The impact of ageing on natural killer cell function and potential consequences for health in older adults


, : The impact of ageing on natural killer cell function and potential consequences for health in older adults. Ageing Research Reviews 12(4): 1069-1078

Forming the first line of defence against virally-infected and malignant cells, natural killer (NK) cells are critical effector cells of the innate immune system. With age, significant impairments have been reported in the two main mechanisms by which NK cells confer host protection: direct cytotoxicity and the secretion of immunoregulatory cytokines and chemokines. In elderly subjects, decreased NK cell activity has been shown to be associated with an increased incidence and severity of viral infection, highlighting the clinical implications that age-associated changes in NK cell biology have on the health of older adults. However, is an increased susceptibility to viral infection the only consequence of these age-related changes in NK cell function? Recently, evidence has emerged that has shown that in addition to eliminating transformed cells, NK cells are involved in many other biological processes such as immune regulation, anti-microbial immune responses and the recognition and elimination of senescent cells, novel functions that involve NK-mediated cytotoxicity and/or cytokine production. Thus, the decrease in NK cell function that accompanies physiological ageing is likely to have wider implications for the health of older adults than originally thought. Here, we give a detailed description of the changes in NK cell biology that accompany human ageing and propose that certain features of the ageing process such as: (i) the increased reactivation rates of latent Mycobacterium tuberculosis, (ii) the slower resolution of inflammatory responses and (iii) the increased incidence of bacterial and fungal infection are attributable in part to an age-associated decline in NK cell function.

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Accession: 036880476

PMID: 23660515

DOI: 10.1016/j.arr.2013.04.003

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Other references

Di Blasi, Colomba; Lanzetta, Mario, 1997: Intrinsic kinetics of isothermal xylan degradation in inert atmosphere. Thermal degradation of thin layers of milled, commercial xylan is made to occur under controlled sample temperature, by proper variation in the intensity of the applied radiative heat flux. The process consists of fast sample heating (40-70 K s-1)...

Ten Have Opbroek A.A.W.; Van Hemert F.J.; De Wolf G.J., 1984: Introduction to immunoembryological studies on the surfactant synthesizing system of the lung. Acta Morphologica Neerlando-Scandinavica 22(2): 175

Miskolzie, M.; Lucyk, S.; Kotovych, G., 2003: NMR conformational studies of micelle-bound orexin-B: a neuropeptide involved in the sleep/awake cycle and feeding regulation. The preferred conformation of orexin-B, an orphan G-protein coupled receptor agonist (the human sequence is RSGPPGLQGRLQRLLQASGNHAAGILTM-NH(2)) has been determined by (1)H and (13)C 2D NMR spectroscopy and molecular modeling. Orexin-B has been imp...

Yang, H.; Carter, R.G.; Zakharov, L.N., 2008: Enantioselective total synthesis of lycopodine. The first enantioselective total synthesis of lycopodine has been completed. Key steps include a highly diastereoselective organocatalyzed cyclization of a keto sulfone to establish the key C-7 and C-8 stereocenters and a tandem 1,3-sulfonyl shif...

Taylor G., 1976: The interaction of immediate and delayed hyper sensitivity reactions. Clinical Allergy: 416

Shim, S; Drake, Mf, 1990: Consumer intention to purchase apparel by mail order: Beliefs, attitude, and decision process variables. The purpose of the study was to investigate consumers' intention to buy apparel items by mail order. More specifically the objectives were (a) to test two conceptual models of consumer behavior in the context of mail order shopping of apparel...

Bonfanti, Marina; Taverna, Stefano; Salmona, Mario; D'incalci, Maurizio; Broggini, Massimo, 1997: P21-WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth. We tested the ability of synthetic peptides derived from p21-WAF1, fused to the internalization peptide sequence derived from Antennapedia, to inhibit the growth of cancer cells in two human ovarian cancer cell lines expressing wild-type p53 or no...

Eldridge, B. F., 1988: Conventional chemical pesticides for mosquito control: past and future. The use of chemical insecticides for the control of mosquitoes in California during 1954-1987 is discussed. The peak year for the use of insecticides was 1958, when over 400 tons were reported used. There has been a gradual but significant decline...

Wettstein Edwards J.; Ticho B.S.; Martin N.C.; Najarian D.; Getz G.S., 1986: In vitro transcription and promoter strength analysis of five mitochondrial transfer rna promoters in yeast saccharomyces cerevisiae. The in vitro transcriptional initiation sites of four yeast mitochondrial tRNA genes have been investigated in a run-off transcription assay. Precise initiation originating within the 9-nucleotide mitochondrial promoter sequence was detected for t...

Ammal, L. Sankari; Bhavanandan, K. V., 1992: Cytological studies on the genus Asplenium Linn. Cytology of seven species of Asplenium namely A. achillifolium (n=120), A. unilaterale (n=80), A. falcatum (2n=ca. 360), A. formosum (n=72), A. indicum (n=36, 2n=72), A. grevellei (n=36, 2n=72), and A. wightianum (n=108) from Kerala and Tamil Nadu...