+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of lixisenatide once daily on gastric emptying in type 2 diabetes – Relationship to postprandial glycemia



Effects of lixisenatide once daily on gastric emptying in type 2 diabetes – Relationship to postprandial glycemia



Regulatory Peptides 185: 1-8



To determine the effects of lixisenatide, a new once-daily (QD) glucagon-like peptide-1 receptor agonist, on postprandial glucose (PPG) and gastric emptying, and the relationship between these effects in patients with type 2 diabetes mellitus (T2DM). Data were obtained from a randomized, double-blind, placebo-controlled, parallel-group study with treatment duration of 28 days in patients with T2DM receiving ?2 oral antidiabetic drugs. Lixisenatide was injected subcutaneously using an ascending dose range (5?20 ?g) increased every fifth day in increments of 2.5 ?g. Blood glucose was determined before and after three standardized meals (breakfast, lunch, and dinner). Gastric emptying of the standardized breakfast was determined by a 13C-octanoic acid breath test at baseline (Day?1) and at Day 28. A total of 21 and 22 patients were randomized to lixisenatide 20 ?g QD and placebo, respectively. With lixisenatide 20 ?g QD, there was a reduction in PPG when compared with placebo after breakfast (p<0.0001), lunch (p<0.0001) and dinner (p<0.05). Hence, lixisenatide 20 ?g administered in the morning exhibited a pharmacodynamic effect on blood glucose throughout the day. Gastric emptying (50% emptying time) increased substantially from baseline with lixisenatide 20 ?g QD, but not with placebo (change from baseline SD: 24.1 133.1 min for placebo and 211.5 278.5 min for lixisenatide; p<0.01).There was an inverse relationship between PPG area under the curve after breakfast and gastric emptying with lixisenatide 20 ?g QD (n=17, r2=0.51, p<0.05), but not with placebo. In this study, lixisenatide at a dose of 20 ?g QD reduced postprandial glycemic excursions in patients with T2DM, possibly as a result of sustained slowing of gastric emptying.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036884730

Download citation: RISBibTeXText

DOI: 10.1016/j.regpep.2013.04.001


Related references

Effects of lixisenatide once daily on gastric emptying in type 2 diabetes--relationship to postprandial glycemia. Regulatory Peptides 185: 1-8, 2013

Effects of lixisenatide on postprandial blood pressure, gastric emptying and glycaemia in healthy people and people with type 2 diabetes. Diabetes Obesity and Metabolism 21(5): 1158-1167, 2019

Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes. Regulatory Peptides 151(1-3): 123-129, 2008

Effects of a D-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care 36(7): 1913-1918, 2013

Contrasting Effects of Lixisenatide and Liraglutide on Postprandial Glycemic Control, Gastric Emptying, and Safety Parameters in Patients With Type 2 Diabetes on Optimized Insulin Glargine With or Without Metformin: A Randomized, Open-Label Trial. Diabetes Care 38(7): 1263-1273, 2015

Gastric Emptying Is More Rapid in Adolescents With Type 1 Diabetes and Impacts on Postprandial Glycemia. Journal of Clinical Endocrinology and Metabolism 100(6): 2248-2253, 2015

Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying--preclinical evidence. Journal of Diabetes and its Complications 28(1): 110-114, 2014

Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin (GetGoal-S). Journal of Diabetes and its Complications 28(3): 386-392, 2015

A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes. Journal of Nutrition 121(6): 795-799, 1991

Prevalence and determinants of solid and liquid gastric emptying in unstable type I diabetes. Relationship to postprandial blood glucose concentrations. Diabetes Care 20(3): 413-418, 1997

Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes. Diabetes Care 32(9): 1600-1602, 2009

Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels. Diabetes Research and Clinical Practice 77(2): 280-285, 2007

Addition of once daily prandial lixisenatide to basal insulin therapy in patients with type-2 diabetes results in a reduction of HbA1c as an effect of postprandial glucose lowering. Diabetes and Metabolic Syndrome 11(Suppl. 1): S91-S97, 2017

Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. American Journal of Clinical Nutrition 95(1): 78-83, 2012

Relationship Between Control of Glycemia and Gastric Emptying Disturbances in Diabetes Mellitus. Clinical Gastroenterology and Hepatology 14(7): 929-936, 2016