+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Positive versus negative sentinel nodes in early breast cancer patients: axillary or loco-regional relapse and survival. A study spanning 2000-2012



Positive versus negative sentinel nodes in early breast cancer patients: axillary or loco-regional relapse and survival. A study spanning 2000-2012



Breast 22(5): 902-907



Sentinel Node Biopsy (SNB) is a minimally invasive alternative to elective axillary lymph node dissection (ALND) for nodal staging in early breast cancer. The present study was conducted to evaluate prognostic implications of a negative sentinel node (SN) versus a positive SN (followed by completion ALND) in a closely followed-up sample of early breast cancer patients. We studied 889 consecutive breast cancer patients operated for 908 primaries. Patients received adjuvant therapy with chemotherapy, hormone therapy and eventually trastuzumab. Radiation therapy was based on tangential radiation fields that usually included axillary level I. Median follow-up was 47 months. Axillary recurrence was seen in 1.2% (2/162) of positive SN patients, and 0.8% (5/625) of negative SN patients (p = n.s.). There was an overall 3.2% loco-regional failure rate (29/908). Incidence of distant recurrence was 3.3% (23/693) for negative SN patients, and 4.6% (9/196) for positive SN patients (p = n.s.). Overall mortality rate was 4% (8/198) for positive SN patients, while the corresponding specific mortality rate was 2.5% (5/198). For patients with negative SNs, overall mortality was 4.9% (34/693), and the specific mortality was 1.4% (19/693) (p = n.s.). We did not find significant differences in axillary/loco-regional relapse, distant metastases, disease-free interval or mortality between SN negative and SN positive patients, with a follow-up over 4 years.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036892773

Download citation: RISBibTeXText

PMID: 23684000

DOI: 10.1016/j.breast.2013.04.015


Related references

Comparison of adjuvant chemotherapy versus loco regional radiotherapy followed by adjuvant chemotherapy in breast cancer patients with 4 or more positive axillary nodes a southeastern cancer study group study. International Journal of Radiation Oncology, Biology, Physics 17(SUPPL 1): 180, 1989

Comparison of adjuvant chemotherapy versus loco-regional radiotherapy followed by adjuvant chemotherapy in breast cancer patients with 4 or more positive axillary nodes: A southeastern cancer study group study. International Journal of Radiation Oncology*biology*physics 17(Supp-S1): 180-0, 1989

A 10-year follow-up of treatment outcomes in patients with early stage breast cancer and clinically negative axillary nodes treated with tangential breast irradiation following sentinel lymph node dissection or axillary clearance. Breast Cancer Research and Treatment 125(3): 893-902, 2011

Risk factors for regional nodal relapse in breast cancer patients with one to three positive axillary nodes. International Journal of Radiation Oncology, Biology, Physics 82(5): 2093-2103, 2012

Loco-regional morbidity after breast conservation and axillary lymph node dissection for early breast cancer with or without regional nodes radiotherapy, perspectives in modern breast cancer treatment: the Skagen Trial 1 is active. Acta Oncologica 56(5): 713-718, 2017

Patterns of relapse and survival in operable breast carcinoma with positive and negative axillary nodes. Tumori 64(3): 241-258, 1978

Patients with breast cancer and positive sentinel nodes: axillary dissection or axillary radiotherapy?. Archives of Surgery 138(10): 1159, 2003

Predictive Value of Primary Tumor Site for Loco-regional Recurrence in Early Breast Cancer Patients with One to Three Positive Axillary Lymphadenophy. Journal of Cancer 8(12): 2394-2400, 2017

Using the volume and the maximum size of metastatic deposits in axillary sentinel lymph nodes of breast cancer patients to predict positive non-sentinel lymph nodes. European Journal of Surgical Oncology 40(5): 640-641, 2014

Predicting loco-regional recurrence risk in T1, T2 breast cancer with 1-3 positive axillary nodes postmastectomy: Development of a predictive nomogram. Indian Journal of Cancer 54(1): 352-357, 2018

Sentinel node mapping breast cancer Can we predict patients with positive sentinel nodes who do not need a completion axillary dissection?. Journal of Nuclear Medicine 42(5 Supplement): 154P, 2001

Personalized axillary dissection: the number of excised lymph nodes of nodal-positive breast cancer patients has no significant impact on relapse-free and overall survival. Journal of Cancer Research and Clinical Oncology 143(9): 1823-1831, 2017

Isolated axillary relapse in patients with breast cancer presenting axillary positive lymph nodes and extranodal tumor invasion. EJC Supplements 2(3): 148-149, March, 2004

Sentinel node mapping performed before preoperative chemotherapy may avoid axillary dissection in breast cancer patients with negative or micrometastatic sentinel nodes. American Journal of Surgery 196(2): 176-183, 2008

The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer 103(10): 2006-2014, 2005