+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Evaluation of essential and toxic trace elements in pseudoexfoliation syndrome and pseudoexfoliation glaucoma



Evaluation of essential and toxic trace elements in pseudoexfoliation syndrome and pseudoexfoliation glaucoma



Biological Trace Element Research 153(1-3): 28-34



Pseudoexfoliation syndrome (PEX), an age-related disorder of the eye, is associated with significant ophthalmic morbidity and can lead to pseudoexfoliation glaucoma (PEG). The etiology of this disorder has not been clearly understood. Trace elements have been suggested to have roles in the pathogenesis of several disorders. This study aimed to determine whether trace element levels have a role in the development of PEX and/or PEG. Levels of zinc (Zn), copper (Cu), selenium (Se), manganese (Mn), chromium (Cr), cobalt (Co), molybdenum (Mo), nickel (Ni), vanadium (V), arsenic (As), aluminum (Al), mercury (Hg), cadmium (Cd), and strontium (Sr) were determined in serum samples of 32 cases of PEX, 30 cases of PEG, and 32 control subjects using inductively coupled plasma-mass spectrometry. Mn, Mo, and Hg concentrations were found to be significantly increased in patients with PEX. Logistic regression revealed Mn and Hg as the strongest determinants of PEX and Mo as the strongest determinant of PEG in the studied Turkish subjects. Levels of Mn, Cr, Co, Mo, Al, Hg, Sr, Ni, V, and As were determined for the first time in these ophthalmological disorders. Increased levels of serum Mn, Mo, and Hg suggest a possible role of these elements in the pathobiology of PEX.

(PDF emailed within 0-6 h: $19.90)

Accession: 036912952

Download citation: RISBibTeXText

PMID: 23512169

DOI: 10.1007/s12011-013-9644-5



Related references

Evaluation of oxidative stress and paraoxonase phenotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Clinical Laboratory 60(1): 79-86, 2014

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Journal of Ophthalmology 2016: 3545180, 2016

Evaluation of the endothelial cell density and the central corneal thickness in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Journal of Ophthalmology 2014: 123683, 2014

Plasma homocysteine, folic acid, and vitamin B₁₂ levels in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and normotensive glaucoma. Medicina 49(5): 214-218, 2014

Comparison of total/active ghrelin levels in primary open angle glaucoma, pseudoexfoliation glaucoma and pseudoexfoliation syndrome. International Journal of Ophthalmology 11(5): 823-827, 2018

Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma. Graefe's Archive for Clinical and Experimental Ophthalmology 243(7): 677-683, 2005

Foveal thickness after phacoemulsification in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, or primary open-angle glaucoma. Journal of Cataract and Refractive Surgery 34(11): 1953-1957, 2008

Foveal thickness after phacoemulsification in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, or primary open-angle glaucoma. Yearbook of Ophthalmology 2009: 66-67, 2009

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management. Journal of Ophthalmology 2015: 370371, 2015

Association between polymorphisms in lysyl oxidase-like 1 and susceptibility to pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Plos One 9(3): E90331, 2015

Conversion rate of Pseudoexfoliation Syndrome to Pseudoexfoliation Glaucoma in a Population-based Study. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 2947, 2002

Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Experimental Eye Research 127: 69-76, 2014

Altered Balance Between Matrix Metalloproteinases And Their Inhibitors In Pseudoexfoliation Syndrome And Pseudoexfoliation Glaucoma. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 3369, 2002

Estimated incidence of pseudoexfoliation syndrome and pseudoexfoliation glaucoma in Olmsted County, Minnesota. Journal of Glaucoma 12(3): 193-197, 2003

Morphometric changes of corneal endothelial cells in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Archivos de la Sociedad Espanola de Oftalmologia 88(11): 439-444, 2014