Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle
Kim, H.; Lee, S.K.; Hong, M.W.; Park, S.R.; Lee, Y.S.; Kim, J.W.; Lee, H.K.; Jeong, D.K.; Song, Y.H.; Lee, S.J.
Animal Genetics 44(6): 750-753
ISSN/ISBN: 0268-9146 PMID: 23718263 DOI: 10.1111/age.12055
The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor-kappa B (NF-κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3'-UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.