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What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens

What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens

Journal of Immunology 190(12): 5913-5918

It is well accepted that Ag-induced B cell differentiation often results in the generation of exceptionally long-lived plasma cells. Much of the work supporting this viewpoint stems from studies focused on germinal center-derived plasma cells secreting high-affinity isotype-switched Abs in mice immunized with T cell-dependent Ags. In contrast, less attention has been devoted to understanding Ab responses to T cell-independent Ags and pathogens. In this study, we review recent work showing that T cell-independent Ags consisting of either polysaccharides or LPSs also induce the formation of long-lived plasma cells, despite their general inability to sustain germinal center responses. This new information provides a framework for more fully understanding the forces underlying immunity to pathogens that resist T cell recognition and the extracellular cues governing plasma cell longevity.

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Accession: 036926444

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PMID: 23749966

DOI: 10.4049/jimmunol.1300161

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