+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Juvenile respiratory papillomatosis: risk factors for severity



Juvenile respiratory papillomatosis: risk factors for severity



Journal of Medical Virology 85(8): 1447-1458



Juvenile recurrent respiratory papillomatosis is caused mainly by human papillomavirus genotypes 6 or 11, acquired at birth or during pregnancy from an infected mother. Recurrent respiratory papillomatosis is characterized by recurring warts growing most commonly in the larynx. Multiple surgical procedures and the risk of airway obstruction contribute to the devastating impact of this disease. Some children will go into remission after a few surgeries whereas others will require repeated interventions over several years. Further understanding of the risk factors associated with severity may contribute to tailored treatments. A retrospective study of cases diagnosed between January 1995 and December 2008 was conducted to study determinants of severe forms of juvenile recurrent respiratory papillomatosis. Demographic and clinical variables were abstracted from children's medical charts and mothers' delivery charts. Viral factors (HPV genotyping and viral load) were studied from archived biopsies. Specific HLA class II alleles and killer-cell immunoglobulin-like receptors genes were tested from saliva samples. Logistic regression was performed to identify risk factors for severity. Overall, 31 pediatric cases of recurrent respiratory papillomatosis were identified. The only significant factor associated with severe forms of recurrent respiratory papillomatosis was the maternal history of condylomas during pregnancy (OR: 12.05 [P=0.05]). The analysis failed to identify risk factors that could be used clinically to identify recurrent respiratory papillomatosis cases likely to take a severe course. Although too early to determine, vaccination against the HPV types involved most commonly in recurrent respiratory papillomatosis may provide the best hope to prevent severe forms of this disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036934377

Download citation: RISBibTeXText

PMID: 23765781

DOI: 10.1002/jmv.23615


Related references

Juvenile onset respiratory papillomatosis: risk factors for severity. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 28(23): 1848-1851, 2014

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy. European Annals of Otorhinolaryngology Head and Neck Diseases 136(1): 25-28, 2019

Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: a systematic review. International Journal of Pediatric Otorhinolaryngology 78(2): 186-197, 2014

Risk factors of juvenile onset recurrent respiratory papillomatosis in the lower respiratory tract. Chinese Medical Journal 125(19): 3496-3499, 2012

Risk factors for juvenile onset recurrent respiratory papillomatosis. Pediatric Infectious Disease Journal 17(5): 372-376, 1998

Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope 114(11 Pt 2 Suppl 104): 1-23, 2004

A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis. Laryngoscope 102(1): 9, 1992

Severity of juvenile onset recurrent respiratory papillomatosis is not associated with socioeconomic status in a setting of universal health care. International Journal of Pediatric Otorhinolaryngology 71(6): 965-972, 2007

Clinical and sociodemographic characteristics associated with disease severity in juvenile recurrent respiratory papillomatosis: A study of 104 patients in a tertiary care pediatric hospital. International Journal of Pediatric Otorhinolaryngology 108: 63-66, 2018

Human papillomatosis genotyping and severity in patients with recurrent respiratory papillomatosis. Journal of the Medical Association of Thailand 97(Suppl. 6): S136-S141, 2014

Risk factors for adult-onset recurrent respiratory papillomatosis. Laryngoscope 124(10): 2338-2344, 2014

Dysplasia in adults with recurrent respiratory papillomatosis: incidence and risk factors. Annals of Otology Rhinology and Laryngology 118(7): 481-485, 2009

Risk factors for aggressive recurrent respiratory papillomatosis in adults and juveniles. Plos one 9(11): E113584, 2014

Risk Factors for Dysplasia in Recurrent Respiratory Papillomatosis in an Adult and Pediatric Population. Annals of Otology Rhinology and Laryngology 125(3): 235-241, 2016

Histopathological features of juvenile-onset laryngeal papillomatosis related to severity. Head and Neck 41(5): 1412-1417, 2019