+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Changes in villus-like projections of corneocytes from the facial skin in normal infants with or without infantile eczema; useful parameter to assess barrier function

Changes in villus-like projections of corneocytes from the facial skin in normal infants with or without infantile eczema; useful parameter to assess barrier function

Skin Research and Technology 19(4): 361-367

Skin barrier function changes rapidly during the first year of life in infants. Measuring skin barrier function in infants is difficult because of the burden on patients and their parents or guardians. A simple method for assessing barrier function in infants that can be performed quickly and would enable swift treatment and skin care management. We used laser microscopy to investigate villus-like projections (VPs) observed on the lower surface of corneocytes obtained on tape strips from 18 normal Japanese infants at the ages of 1, 3, and 6 months. We also performed transepidermal water loss and corneocyte size measurements. A dermatologist clinically assessed the cutaneous findings. We rapidly measured skin barrier function changes during the first 6 months of life in infants. During the study period, very slight erythema and pityriasis were the primary reasons for skin rash, which were generally most severe at 3 months. The results showed that barrier function declined at approximately 3 months of age in nearly all subjects. Therefore, we found that normal barrier function of infantile skin becomes temporarily impaired after birth. We conclude that even in patients with very mild skin rashes, multiple objective indices of skin barrier function deteriorate simultaneously. Observation of VPs on the surface of corneocytes using laser microscopy is a rapid, painless, and effective method of monitoring skin barrier function in infants, and VP score offers a useful index for assessing barrier function.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036950219

Download citation: RISBibTeXText

PMID: 23800104

DOI: 10.1111/srt.12044

Related references

Scanning and transmission electron microscopic study of corneocytes: experimental formation of villus-like projections of the corneocytes of human epidermis by keratin layer stripping technique using cyanoacrylate. Nihon Hifuka Gakkai Zasshi. Japanese Journal of Dermatology 98(14): 1467-1473, 1988

Skin Barrier Function and Staphylococcus aureus Colonization in Vestibulum Nasi and Fauces in Healthy Infants and Infants with Eczema: A Population-Based Cohort Study. Plos one 10(6): E0130145, 2015

Scanning electron microscopic and biochemical study of the corneocytes cc with villus like projections vp. Clinical Research 37(2): 711A, 1989

Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis. Journal of Dermatological Science 76(3): 231-239, 2014

The demonstration of lysosomes in the diseased skin of infants with infantile eczema. Journal of Investigative Dermatology 45(6): 448-457, 1965

The barrier function of normal skin. Morphologic and functional aspects of the skin barrier. Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 65(3): 234-240, 2014

Using skin models to assess the effects of a protection cream on skin barrier function. Skin Pharmacology and Physiology 17(4): 167-175, 2004

The effect of a daily facial cleanser for normal to oily skin on the skin barrier of subjects with acne. Cutis 78(1 Suppl): 34-40, 2006

Skin barrier function, epidermal proliferation and differentiation in eczema. Journal of Dermatological Science 43(3): 159-169, 2006

Weaning to Hypoallergenic Formula Improves Gut Barrier Function in Breast-Fed Infants With Atopic Eczema. Journal of Pediatric Gastroenterology and Nutrition 38(1): 92-96, 2004

Weaning to hypoallergenic formula improves gut barrier function in breast-fed infants with atopic eczema. Journal of Pediatric Gastroenterology and Nutrition 38(1): 92-96, 2004

Circadian changes in the size of facial skin corneocytes of healthy women. Annual Review of Chronopharmacology : 331-334, 1990

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 65(7): 911-918, 2010

The effects of benzylsulfonyl-D-Ser-homoPhe-(4-amidino-benzylamide), a dual plasmin and urokinase inhibitor, on facial skin barrier function in subjects with sensitive skin. International Journal of Cosmetic Science 39(2): 109-120, 2017

Comparison of the results of some diagnostic function tests in infantile eczema with special reference to atopic eczema. Ceskoslovenska Dermatologie 37: 236-240, 1962