+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Plasmacytoma-like post-transplant lymphoproliferative disorder seen in pediatric combined liver and intestinal transplant recipients



Plasmacytoma-like post-transplant lymphoproliferative disorder seen in pediatric combined liver and intestinal transplant recipients



Pediatric Blood and Cancer 60(11): E137



Post-transplant lymphoproliferative disease (PTLD) is a lymphoproliferative disorder secondary to chronic immunosuppression and is the most common malignancy in transplanted patients [Kamdar et al. Curr Opin Organ Transplant, 2011; 16:274-280]. Although PTLD usually presents as B or T cell lymphoma, plasmacytomas have been reported, mostly in the adult population. Six cases of pediatric plasmacytoma-like PTLD have been reported, all of which were treated with vincristine, adriamycin, and dexamethasone (VAD), high dose dexamethasone alone, or dexamethasone + thalidomide [Tcheng et al. Pediatric Blood Cancer, 2006; 47:218-223; Perry et al. Blood, 2013; 8:1377-1383]. We present two cases of pediatric plasmacytoma-like PTLD in combined liver and small bowel transplant patients both successfully treated with bortezomib and dexamethasone based on multiple myeloma protocols [Kyle and Rajkumar, Clin Lymphoma Myeloma, 2009; 9:278-288; Adams and Kaufmann, Cancer Invest, 2004; 22:304-311].

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036953642

Download citation: RISBibTeXText

PMID: 23813867

DOI: 10.1002/pbc.24632


Related references

Post-transplant lymphoproliferative disorder in pediatric intestinal transplant recipients: A literature review. Pediatric Transplantation 22(5): E13211, 2018

The use of objective case ascertainment to identify risk factors for Epstein-Barr virus-associated post-transplant lymphoproliferative disorder in pediatric liver transplant recipients. Hepatology 36(4 Part 2): 662A, 2002

Plasmablastic plasmacytoma-like post-transplant lymphoproliferative disorder in an orthotopic liver transplant. Digestive and Liver Disease 48(7): 826-827, 2016

Post-transplant lymphoproliferative disorder in pediatric heart transplant recipients. Journal of Heart and Lung Transplantation 29(6): 648-657, 2010

Adenotonsillar hypertrophy and post-transplant lymphoproliferative disorder in pediatric renal transplant recipients. Pediatric Nephrology 19(4): 471-472, 2004

Chromosome abnormalities associated with post-transplant lymphoproliferative disorder in pediatric bone marrow transplant recipients. Blood 102(11): 277b, 2003

Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. Pediatric Transplantation 8(3): 243-248, 2004

Surveillance of Epstein-Barr virus infection as a risk factor for post-transplant lymphoproliferative disorder in pediatric renal transplant recipients. Pediatric Nephrology 19(4): 365-368, 2004

Post-transplant lymphoproliferative disorder: no relationship to recombinant human growth hormone use in Australian and New Zealand pediatric kidney transplant recipients. Pediatric Transplantation 17(8): 731-736, 2013

Post-transplant lymphoproliferative disorder in adult liver transplant recipients: a South American multicenter experience. Clinical Transplantation 27(4): E469-E477, 2014

Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study. Pediatric Transplantation 21(6):, 2017

Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients. Pediatric Transplantation 5(5): 359-364, 2001

Risk factors and clinical outcomes of pediatric liver transplant recipients with post-transplant lymphoproliferative disease in a multi-ethnic Asian cohort. Transplant Infectious Disease 20(1):, 2018

Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients. Clinical Transplantation 20(3): 389-393, 2006

Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience. American Journal of Transplantation 5(4 Pt 1): 775-780, 2005