+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Coinfection of hepatitis B and hepatitis delta virus in Belgium: a multicenter BASL study. Prospective epidemiology and comparison with HBV mono-infection



Coinfection of hepatitis B and hepatitis delta virus in Belgium: a multicenter BASL study. Prospective epidemiology and comparison with HBV mono-infection



Journal of Medical Virology 85(9): 1513-1517



Epidemiological data on hepatitis delta virus (HDV) infection in Belgium are lacking. A multicenter questionnaire-based registry on HDV infection was collated between March 1, 2008 and February 28, 2009. It consisted of patients coinfected with hepatitis B virus (HBV) and HDV. The data samples were compared to those of a concurrent registry on HBV infection. Prospective data of patients with HBV-HDV coinfection were collected. Active HBV replication is defined as HBeAg positivity or HBV DNA > 2,000 IU/ml. Forty-four patients from 15 centers were registered. A comparison of 29 patients infected with HDV (registered in the concurrent HBV registry) was made against 785 HBV mono-infected patients. The seroprevalence of patients coinfected with HBV and HDV in Belgium is reported to be 3.7% (29/785), consisting solely of the HBV-HDV coinfected patients in the HBV registry. This rises to 5.5% (44/800) if all patients infected with HDV from the two registries combined are included. The patients coinfected with HBV and HDV had higher (P < 0.05) ALT values and more advanced liver disease (Metavir score ≥F2), but had less active HBV replication and lower HBV DNA titers when compared with the patients infected only with HBV. Additionally, the majority of HBV-HDV coinfected patient was male, and 13.6% (6/44) of the patients that were coinfected HBV and HDV were also infected with HCV. In conclusion, this study provided much needed epidemiological data on the current state of HDV infection in Belgium.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036974163

Download citation: RISBibTeXText

PMID: 23852675

DOI: 10.1002/jmv.23653


Related references

Histological and Serological Epidemiology of Hepatitis Delta Virus Coinfection among Patients with Chronic Active Hepatitis B Virus in Razavi Khorasan Province, Northeastern Iran. Iranian Journal of Public Health 47(12): 1906-1912, 2018

Role of hepatitis B, hepatitis C and hepatitis delta virus in dual and triple chronic hepatitis coinfection. Journal of Hepatology 34(Suppl. 1): 122, 2001

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection. World Journal of Gastroenterology 25(13): 1566-1579, 2019

High doses of alpha-interferon are required in chronic hepatitis due to coinfection with hepatitis B virus and hepatitis C virus: long term results of a prospective randomized trial. American Journal of Gastroenterology 96(10): 2973-2977, 2001

Search for hepatitis delta virus (HDV) infection in hepatitis C patients in northeastern Poland. Comparison with anti-HDV prevalence in chronic hepatitis B. European Journal of Epidemiology 18(6): 559-561, 2003

Search for Hepatitis Delta Virus (Hdv) Infection in Hepatitis C Patients in North-Eastern Poland. Comparison with Anti-Hdv Prevalence in Chronic Hepatitis B. European Journal of Epidemiology 18(6): 559-561, 2003

Comparable ten-year outcome in hemodialysis patients with hepatitis C virus and hepatitis B virus coinfection and single hepatitis B virus infection. Blood Purification 32(2): 89-95, 2011

Heterosexual transmission of hepatitis delta virus in the general population of an area endemic for hepatitis B virus infection: a prospective study. Journal of Infectious Diseases 162(5): 1170-1172, 1990

Why most patients with hepatitis delta virus infection are seronegative for hepatitis B e antigen. A prospective controlled study. Journal of Hepatology 12(1): 106-109, 1991

Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multicenter Study. Transplantation 100(7): 1507-1512, 2016

Liver decompensation in HIV/Hepatitis B coinfection in the combination antiretroviral therapy era does not seem increased compared to hepatitis B mono-infection. Liver International 39(3): 470-483, 2019

Transplantation of hepatitis B surface antigen-positive livers into hepatitis B virus-positive recipients and the role of hepatitis delta coinfection. Liver Transplantation 11(8): 922-928, 2005

Role of lamivudine in the posttransplant prophylaxis of chronic hepatitis B virus and hepatitis delta virus coinfection. Transplantation 83(10): 1341-1344, 2007

Hepatitis B virus replication in acute hepatitis B, acute hepatitis B virus-hepatitis delta virus coinfection and acute hepatitis delta superinfection. Hepatology 7(3): 569-572, 1987

Acquired hepatocerebral degeneration in a patient with hepatitis B and hepatitis delta virus coinfection. Revista Da Sociedade Brasileira de Medicina Tropical 50(3): 423-426, 2017