EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders


Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders



Isrn Pharmaceutics 2013: 674507



ISSN/ISBN: 2090-6145

PMID: 23956881

DOI: 10.1155/2013/674507

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation were undertaken with a view to develop a fast disintegrating tablet of salbutamol sulphate which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as sodium starch glycolate was optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time, and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug-excipient compatibility, and accelerated stability study. It was concluded that fast disintegrating tablets of salbutamol sulphate were formulated successfully with desired characteristics which disintegrated rapidly; provided rapid onset of action; and enhanced the patient convenience and compliance.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036976800

Download citation: RISBibTeXText

Related references

Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate, cetirizine hydrochloride in combined pharmaceutical dosage form: a new era in novel drug delivery for pediatrics and geriatrics. Journal of Drug Delivery 2015: 640529, 2015

A Comparative Study of Different Proportions of Superdisintegrants: Formulation and Evaluation of Orally Disintegrating Tablets of Salbutamol Sulphate. Turkish Journal of Pharmaceutical Sciences 14(1): 40-48, 2017

Formulation Development and evaluation of fast disintegrating tablets of Lamotrigine using liqui-solid technique. International Journal of Pharmaceutical Investigation 4(4): 207-214, 2014

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets. Journal of Drug Delivery 2014: 827035, 2014

Formulation development and characterization of fast disintegrating tablets of Nimesulide. Stamford Journal of Pharmaceutical Sciences 4(2): 25-28, 2012

Formulation study for lansoprazole fast-disintegrating tablet. III. Design of rapidly disintegrating tablets. Chemical and Pharmaceutical Bulletin 51(10): 1121-1127, 2003

The role of formulation excipients in the development of lyophilised fast-disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik E.V 72(1): 119-129, 2009

A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation. Drug Delivery and Translational Research 7(3): 450-459, 2017

Formulation and evaluation of diclofenac potassium fast-disintegrating tablets and their clinical application in migraine patients. Drug Development and Industrial Pharmacy 37(3): 260-267, 2011

Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins. Pharmaceutical Development and Technology 18(2): 367-376, 2013

Piperine fast disintegrating tablets comprising sustained-release matrix pellets with enhanced bioavailability: formulation, in vitro and in vivo evaluation. Pharmaceutical Development and Technology 25(5): 617-624, 2020

Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets. Journal of young pharmacists: JYP 2(3): 234-239, 2010

Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics. Aaps Pharmscitech 18(5): 1624-1633, 2017

Formulation design of fast disintegrating tablets using disintegrant blends. Indian journal of pharmaceutical sciences 72(1): 130-133, 2010

Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug Development and Industrial Pharmacy 31(1): 25-34, 2005