+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Colloid-Richa follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens Cytologic, histologic, and molecular basis for considering an alternate view



Colloid-Richa follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens Cytologic, histologic, and molecular basis for considering an alternate view







Typically, thyroid follicular neoplasm/suspicious for follicular neoplasm (FN/SFN) cases show moderate to marked cellularity and scant or absent colloid. Recently, cases have been noted with microfollicular cellularity in the background of moderate to abundant amount of colloid. The purpose of this study was to compare these a ocolloid-richa FN/SFN cases to the typical FN/SFN cases.Thyroid cytology specimens with the features of FN/SFN were searched in cytopathology files from September 2008 to June 2012. Cases with absent or minimal colloid were designated a otypical colloid-poora FN/SFN and cases with moderate to abundant colloid were designated a ocolloid-richa FN/SFN. From these cases, those with surgical pathology resection follow-up were identified. Cytologic, surgical pathology resection, and molecular features (BRAF, RAS, RET/PTC, and PAX8-PPAR ) were investigated for the typical colloid-poor FN/SFN cases and were compared with those of the colloid-rich FN/SFN cases. Of 431 FN/SFN cases with surgical pathology resection follow-up, 360 (83.5%) cases showed features of typical colloid-poor FN/SFN and 71 (16.5%) cases showed features of colloid-rich FN/SFN. Papillary carcinoma was the most common malignant outcome for the 2 groups. Although the proportion of malignant outcome was similar for the 2 groups, the a ocolloid-richa FN/SFN cases showed a greater proportion of nodular hyperplasia among the cases with benign outcome. In addition, the a ocolloid-richa FN/SFN cases demonstrated a greater proportion of cases with a mutation. Approximately one-sixth of cases of FN/SFN show a ocolloid-richa features. Comparison to the typical colloid-poor FN/SFN demonstrated similar risk for malignancy but contrasting resection outcome and molecular characteristics. Cancer (Cancer Cytopathol) 2013.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 037019058

Download citation: RISBibTeXText

DOI: 10.1002/cncy.21333


Related references

"Colloid-rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: cytologic, histologic, and molecular basis for considering an alternate view. Cancer Cytopathology 121(12): 718-728, 2013

Factors that predict malignant thyroid lesions when fine-needle aspiration is "suspicious for follicular neoplasm". Mayo Clinic Proceedings 72(10): 913-916, 1997

Follicular neoplasm of the thyroid gland: unique cytologic appearances in a fine-needle aspiration biopsy. Diagnostic Cytopathology 38(9): 660-662, 2010

Clinical significance of distinguishing between follicular lesion and follicular neoplasm in thyroid fine-needle aspiration biopsy. Annals of Surgical Oncology 16(11): 3146-3153, 2009

Diagnosis of follicular neoplasm in thyroid nodules by fine needle aspiration cytology: does the result, benign vs. suspicious for a malignant process, in these nodules make a difference?. Acta Cytologica 53(5): 517-523, 2009

Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration?. Diagnostic Cytopathology 34(5): 330-334, 2006

Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay. Cancer 120(23): 3627-3634, 2014

Can noninvasive follicular thyroid neoplasm with papillary-like nuclear features be distinguished from classic papillary thyroid carcinoma and follicular adenomas by fine-needle aspiration?. Cancer Cytopathology 125(6): 378-388, 2017

The predictive value of the fine-needle aspiration diagnosis "suspicious for a follicular neoplasm, hurthle cell type" in patients with hashimoto thyroiditis. American Journal of Clinical Pathology 135(1): 139-145, 2011

Diagnosis of thyroid follicular neoplasm: fine-needle aspiration versus core-needle biopsy. Thyroid 24(11): 1612-1617, 2014

Diagnosis of Follicular Neoplasm in Thyroid Nodules by Fine Needle Aspiration Cytology. Acta Cytologica 53(5): 517-523, 2009

Does the fine-needle aspiration diagnosis of "Hürthle-cell neoplasm/follicular neoplasm with oncocytic features" denote increased risk of malignancy?. Diagnostic Cytopathology 31(5): 307-312, 2004

Diagnosis of follicular neoplasm: A gray zone in thyroid fine-needle aspiration cytology. Diagnostic Cytopathology 26(1): 41-44, 2002

Fine needle aspiration cytology of thyroid follicular neoplasm: cytohistologic correlation and accuracy. Korean Journal of Pathology 47(1): 61-66, 2013

Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47. Surgery 116(6): 1031-1035, 1994