+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Seven year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healingdevelopment of a validated scoring system



Seven year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healingdevelopment of a validated scoring system



Colorectal Disease



The management of enterocutaneous fistulae (ECF) is complex and challenging. We have examined factors associated with fistula healing at a National Intestinal Failure Centre, and have devised the first scoring system to predict spontaneous fistula healing prior to surgery. A retrospective audit of 177 patients (mean age: 48.7 years) treated over seven years was undertaken. were compared to a previously reported series from this unit.Univariate and multivariate analysis was performed on variables to assess relationship with ECF healing. A scoring system was devised and validated on a prospective cohort. 150 patients underwent surgery between January 2003 and December 2009. Overall healing rate following surgery in the current series was 94.6% (82% in the previous series). Mean delay from previous surgery to current operation was one year compared with eight months. Thirty -day post fistula resection mortality was 0% (compared with 3.5% previously). Twenty seven patients underwent medical management alone with overall healing rate of 46.4% (vs 19.9%). Of the prospective cohort of 85 patients, multivariate analysis revealed that co-morbidity (p = 0.02), source of referral (p = 0.01) and aetiology (p = 0.006) had associations with healing. Almost all patients with a score of zero and one healed, whilst highest scores healed least frequently. Surgical management of ECF is safe and improving. Fistula healing is affected by aetiology, co-morbidity and source of referral. The scoring system has potential to predict ECF healing and can be a useful clinical decision making tool.This article is protected by copyright. All rights reserved.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 037154117

Download citation: RISBibTeXText

DOI: 10.1111/codi.12363


Related references

Seven-year experience of enterocutaneous fistula with univariate and multivariate analysis of factors associated with healing: development of a validated scoring system. Colorectal Disease 15(9): 1162-1170, 2014

A 16-year experience with 1275 primary living donor kidney transplants: univariate and multivariate analysis of risk factors affecting graft survival. Transplantation Proceedings 28(3): 1578-1579, 1996

Multivariate and univariate analysis of prognostic factors following resection in HCC: the Birmingham experience. Digestive Surgery 23(1-2): 103-109, 2006

Univariate and multivariate analysis of risk factors for graft failure after liver transplants A single-center experience. Hepatology. 24(4 Part 2): 504a, 1996

An 11-year experience of enterocutaneous fistula. British Journal of Surgery 91(12): 1646-1651, 2004

Clinical and Histological Prognostic Factors in Axillary Node-Negative BreastCancer: Univariate and Multivariate Analysis with Relation to 5-Year Recurrence. Breast Cancer 2(1): 51-58, 1995

Single center experience of 1000 primary living donor kidney transplants: univariate and multivariate analysis of risk factors affecting graft survival. Transplantation Proceedings 26(4): 2159-2160, 1994

Definitive surgical treatment of enterocutaneous fistula: outcomes of a 23-year experience. JAMA Surgery 148(2): 118-126, 2013

Surgery for high-output small bowel enterocutaneous fistula: a 30-year experience. International Surgery 94(3): 262-268, 2010

Prognostic factors in gestational trophoblastic tumors a proposed new scoring system based on multivariate analysis. American Journal of Obstetrics & Gynecology 164(2): 611-616, 1991

Factors linked to 5-year survival after hepatectomy for hepatocellular carcinoma: univariate and multivariate analyses of 312 patients. Fukuoka Igaku Zasshi 90(7): 324-328, 1999

Validated univariate and multivariate spectrophotometric methods for the determination of pharmaceuticals mixture in complex wastewater. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 140: 451-461, 2015

Risk factors in non hodgkin lymphomas univariate vs. multivariate analysis. Uicc (Union Internationale Contre Le Cancer, International Union Against Cancer) 14th International Cancer Congress, Budapest, Hungary, Aug 21-27, Abstracts, Lectures, Symposia And Free Communications, Vols 1, 2, 3, Late Abstracts, And Register Xvi+479p (Vol 1); Xvi+298p (Vol 2); Xvi+531p (Vol 3); 15p (Late Abstracts); 40p (Register) S Karger Ag: Basel, Switzerland; New York, N Y , Usa; Akademiai Kiado: Budapest, Hungary Paper 333, 1986

Adenocarcinoma of the stomach: univariate and multivariate analysis of factors associated with survival. American Journal of Clinical Oncology 25(1): 84-89, 2002