+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

First-degree relatives of early-onset gastric cancer patients show a high risk for gastric cancer: phenotype and genotype profile



First-degree relatives of early-onset gastric cancer patients show a high risk for gastric cancer: phenotype and genotype profile



Virchows Archiv 463(3): 391-399



First-degree relatives (FDR) of early-onset gastric cancer (EOGC) is presumed to be a population with a distinct molecular and phenotypic profile, regarding the prevalence of gastric premalignant conditions and the association with Helicobacter pylori infection and host proinflammatory gene polymorphisms. A case-control study was conducted with FDR of EOGC patients (n = 103) and age and gender matched controls (n = 101; ranging from spouses to neighbors and dyspeptics). Upper endoscopy was performed, Operative Link on Gastritis Assessment (OLGA) system used for staging and H. pylori (cagA and vacA) and host IL1B-511, IL1RN intron2 VNTR and IFNGR1-56 genotyping. Seventy percent of cases showed atrophy, while 19 % presented with high-stage gastritis (OLGA stage III or IV) (p < 0.001); gastric dysplasia was present in seven cases (vs none in controls) (p = 0.007). In cases, H. pylori was present in 82 % (vs 62 % in controls; p = 0.004) with vacA s1 and vacA m1 + strains significantly associated with the presence of atrophy; individuals homozygous for IL1B-511*T present a significantly higher risk for dysplasia. An increased global prevalence of IFNGR1-56*T/*T polymorphism (37 % in cases vs 24 % in controls; p = 0.03) was observed with no association with atrophic changes or dysplasia. All trends observed were kept when comparing FDR of EOGC with spouses, neighbors, or dyspeptic controls. We demonstrated that FDR of EOGC patients have an increased prevalence of high-risk OLGA stages and dysplasia that seem to be associated with high virulence H. pylori strains and pro-inflammatory host genotypes, including a possible population-specific risk marker. FDR of EOGC patients may merit specific management through endoscopic and histopathological adequate assessment of gastric mucosa and surveillance.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 037250083

Download citation: RISBibTeXText

PMID: 23887584

DOI: 10.1007/s00428-013-1458-5


Related references

Mo1556 High-Risk Host Genotype and H. pylori Strains in First Degree Relatives of Patients With Early-Onset Gastric Cancer. Gastroenterology 142(5): S-627-S-628, 2012

First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia. Alimentary Pharmacology and Therapeutics 35(12): 1451-1459, 2012

M1951 Are First Degree Relatives of Gastric Cancer Patients At An Increased Risk for Gastric Cancer? a Meta-Analysis. Gastroenterology 136(5): A-454, 2009

Classification of gastritis in first-degree relatives of patients with gastric cancer in a high cancer-risk area in Italy. Anticancer Research 32(5): 1711-1716, 2012

Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. British Journal of Cancer 82(11): 1795-1800, 2000

Cancer Worry, Perceived Risk and Cancer Screening in First-Degree Relatives of Patients with Familial Gastric Cancer. Journal of Genetic Counseling 25(3): 520-528, 2017

Higher gastric mucin secretion and lower gastric acid output in first-degree relatives of gastric cancer patients. Journal of Clinical Gastroenterology 42(1): 36-41, 2007

MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer. Tumour Biology 31(1): 23-32, 2010

Early gastric cancer in the province of Forli: Follow-up of 337 patients in a high risk region for gastric cancer. Oncology Reports 5(4): 945-948, 1998

What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World Journal of Gastroenterology 23(13): 2435-2442, 2018

Gastric mucin expression in first-degree relatives of gastric cancer patients. European Journal of Gastroenterology and Hepatology 26(7): 710-714, 2015

Gastric mucosa alterations in first-degree relatives of gastric cancer patients. Anticancer Research 25(3c): 2567-2572, 2005

Sa1545 The Incidence of Metachronous Gastric Cancer After Endoscopic Resection of Early Gastric Cancer According to the Degree of Differentiation of the Primary Gastric Cancer. Gastrointestinal Endoscopy 81(5): Ab255-Ab256, 2015

Targeted screening for prostate cancer in high risk families: Early onset is a significant risk factor for disease in first degree relatives. Journal of Urology 168(2): 483-487, 2002

Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients. European Journal of Gastroenterology and Hepatology 11(7): 717-720, 1999