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Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner

Terrier, O.; Diederichs, A.; Dubois, J.; Cartet, Gëlle.; Lina, B.; Bourdon, J-Christophe.; Rosa-Calatrava, M.

Febs Letters 587(18): 2965-2971

2013


ISSN/ISBN: 0014-5793
PMID: 23954291
DOI: 10.1016/j.febslet.2013.08.006
Accession: 037434163

The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of IAV infection on p53 stability and transcriptional activity. Our results indicate that IAV-induced stabilization of p53 only partially correlates with modulation of p53 transcriptional activity measured during infection. Moreover, we show that the viral non-structural protein 1 (NS1) is able to inhibit p53 transcriptional activity, in a promoter-dependent manner. Based on these data, we propose that NS1 may contribute to p53-mediated cell fate decision during IAV infection. p53 physically interacts with NS1 by anti bait coimmunoprecipitation (View interaction).

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