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Atrial natriuretic factor ANF stimulates the release of -MSH from frog neurointermediate lobes in vitro Interaction with dopamine, GABA and neuropeptide Y



Atrial natriuretic factor ANF stimulates the release of -MSH from frog neurointermediate lobes in vitro Interaction with dopamine, GABA and neuropeptide Y



Life Sciences 4019: 1853-1857



The action of atrial natriuretic factor (ANF) on .alpha.-MSH release from frog neurointermediate lobe was studied in vitro using a perifusion technique. Synthetic ANF Arg101-Tyr126, at concentrations ranging from 10-7 to 10-5 M, caused a dose-related stimulation of .alpha.-MSH release. In addition, dopamine, GABA and NPY, three neuroendocrine factors which inhibit .alpha.-MSH secretion totally suppressed the action of ANF on .alpha.-MSH production. The neural lobe of the amphibian pituitary contains numerous ANF immunoreactive fibers, and this regulatory peptide may diffuse from nerves terminating in the pars nervosa to the pars intermedia. Thus, our results suggest that ANF of hypothalamo-neurohypophysial origin may be involved in the multineuronal regulation of amphibian melanotrophs.

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