+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic effects of mianserin on noradrenaline metabolism in the rat brain: evidence for a pre-synaptic alpha-adrenolytic action in vivo



Chronic effects of mianserin on noradrenaline metabolism in the rat brain: evidence for a pre-synaptic alpha-adrenolytic action in vivo



Psychopharmacology 64(3): 329-332



Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the normetanephrine concentration in the amygdaloid cortex and decreases it in the mid-brain. Mianserin had a qualitatively similar action to that of yohimbine. When given clinically to rats in combination with clonidine, mianserin antagonizes both the depression of behaviour of the rats in the 'open field' apparatus and also the effects of the alpha-agonist in reducing the concentration of normetanephrine in the amygdaloid cortex. It thus appears that the chronic effects of mianserin are due to an increase in noradrenaline release as a consequence of the inhibitation of pre-synaptic alpha-adrenoreceptors.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 038921674

Download citation: RISBibTeXText

PMID: 41280


Related references

The action of the antidepressant drug mianserin on pre-synaptic alpha-adrenergic receptors in the rat brain in vivo. Neuropharmacology 17(12): 1058-1060, 1978

Influence of chronic treatment with mianserin m and protriptyline pt on alpha 1 adrenoceptor density and noradrenaline stimulated metabolism of phosphoinositides in the cerebral cortex of the rat. Revista de Farmacologia Clinica y Experimental 4(3): 213, 1987

Differential effects of chronic treatment with mianserin and protriptyline on rat brain cortical alpha 1 adrenoceptors. Brain Research 498(2): 366-370, 1989

Affinity of a 1,4-benzodioxane derivative with alpha-adrenolytic activity to isolated synaptic membranes from rat brain. Acta Physiologica et Pharmacologica Bulgarica 17(2-3): 118-121, 1991

Differential blockade by (-)mianserin of the alpha 2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes. Naunyn-Schmiedeberg's Archives of Pharmacology 322(2): 180-182, 1983

The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the 'open field' behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat. Neuropsychobiology 18(3): 118-121, 1987

The Effect of Chronically Administered Mianserin, 8-Hydroxymianserin and Desmethylmianserin on the Open Field Behaviour and Brain Noradrenaline Metabolism in the Olfactory Bulbectomized Rat. Neuropsychobiology 18(3): 118-121, 1987

Effects of mianserin on noradrenaline uptake, cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors in rats. British Journal of Pharmacology 66(1): 132p-133p, 1979

Effect of chronic administration of the 6 aza analogue of mianserin org 3770 and its enantiomers on behavior and changes in noradrenaline metabolism of olfactory bulbectomized rat in the open field apparatus. Neuropharmacology 25(3): 267-270, 1986

Evidence for functional separation of alpha-1 and alpha-2 noradrenaline receptors by pre-synaptic terminal re-uptake mechanisms. Psychopharmacology 103(3): 366-374, 1991

Hypotensive action of noradrenaline and alpha methyl noradrenaline in the area of the nucleus tractus solitarii in the rat brain stem. Davies, Donald S And John L Reid (Ed ) Central Action Of Drugs in Blood Pressure Regulation Proceedings Of An International Symposium London, England, Xi+306p Illus University Park Press: Baltimore, Md , U S A ; London, England ISBN 0-8391-0800-1: 179-180, 1975

Acute effects on nomifensine on in vivo uptake and metabolism of dopamine noradrenaline and serotonin in the rat brain. Pharmacology & Toxicology 60(1): 70-74, 1987

Effects of chronic exposure to desipramine and mianserin on Ca2+ mobilization induced by noradrenaline, acetylcholine, and high K+ in rat frontocortical neurons. Neuropsychobiology 33(2): 66-70, 1996

Effects of Chronic Exposure to Desipramine and Mianserin on Ca 2+ Mobilization Induced by Noradrenaline, Acetylcholine, and High K + in Rat Frontocortical Neurons. Neuropsychobiology 33(2): 66-70, 1996

Comparative effects of clozapine and alpha-adrenoceptor blocking drugs on regional noradrenaline metabolism in rat brain. European Journal of Pharmacology 52(2): 225-230, 1978