Section 39
Chapter 38,932

Dopaminergic neuronal responses to a non-amphetamine CNS stimulant

German, D.C.; Harden, H.; Sanghera, M.K.; Mann, D.; Kiser, R.S.; Miller, H.H.; Shore, P.A.

Journal of Neural Transmission 44(1-2): 39-49


PMID: 35584
DOI: 10.1007/bf01252700
Accession: 038931278

Download citation:  

The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid--DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with alpha-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.

PDF emailed within 0-6 h: $19.90