EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Gold-induced changes in the morphology and functional capabilities of human monocytes


Gold-induced changes in the morphology and functional capabilities of human monocytes



Arthritis and Rheumatism 22(12): 1352-1360



ISSN/ISBN: 0024-4082

PMID: 117813

DOI: 10.1002/art.1780221206

The capacity of gold compounds to induce morphologic changes and alterations in the functional activity of human mononuclear phagocytes (M phi) in vitro was examined. Human peripheral blood mononuclear cells were incubated with gold sodium thiomalate (25 microgram/ml) for 96 hours. As a result, M phi developed electron dense precipitates within phagolysosomes, as well as marked dilatation of these organelles. Gold incubation also altered a number of M phi functions. While viability and adherence were unaffected, the capacity to spread on surfaces was diminished. Pinocytosis of soluble proteins and phagocytosis of opsonized sheep erythrocytes were impaired, but Fc mediated particle binding was not. These data indicate that gold can alter certain functional activities of M phi and support the idea that the major action of gold in rheumatoid arthritis results from its capacity to alter M phi function.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 038942698

Download citation: RISBibTeXText

Related references

Modulation of the morphology and glycosaminoglycan biosynthesis of human monocytes, induced by culture substrates. Biochemical Journal 219(3): 793-799, 1984

Functional capabilities of bacterial biofilms on gold particles. Fems Microbiology Ecology 96(1), 2020

Functional relationship of human T lymphocytes, monocytes and interleukins. II. Helper requirements for phytohaemagglutinin-induced proliferation of human T-lymphocyte colony-forming cells. Scandinavian Journal of Immunology 18(2): 137-143, 1983

Functional relationship of human t lymphocytes monocytes and interleukins 2. helper requirements for phyto hem agglutinin induced proliferation of human t lymphocyte colony forming cells. Scandinavian Journal of Immunology 18(2): 137-144, 1983

Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR. Journal of Immunology 130(2): 706-711, 1983

Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes. International Immunopharmacology 35: 85-98, 2016

Interleukin-2 enhances antigen presentation capabilities of human monocytes Implications for cancer vaccines. Proceedings of the American Association for Cancer Research Annual Meeting 39: 354, 1998

Manganite Heterojunction Photodetector with Broad Spectral Response Range from 200 nm to 2 μm. Micromachines 11(2), 2020

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo 3 Ubiquinol Oxidase from Escherichia coli. Chemmedchem 15(14): 1262-1271, 2020

Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infection and Immunity 79(10): 3957-3965, 2011

Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors. Clinical and Vaccine Immunology: Cvi 21(4): 534-545, 2014

Functional subsets of human monocytes defined by monoclonal antibodies: a distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture. Journal of Immunology 130(2): 698-705, 1983

T7 bacteriophage induced changes of gold nanoparticle morphology: biopolymer capped gold nanoparticles as versatile probes for sensitive plasmonic biosensors. Analyst 139(14): 3563-3571, 2014

Evaluation of the antibody-dependent cytotoxic capabilities of individual human monocytes. Role of FccRI and FccRII and the effects of cytokines at the single cell level. Journal of Immunology 145: 83-9, 1990

Monocytes oxidize gold drug into the immunogenic metabolite gold Demonstration by gold -specific T cells in the popliteal lymph node assay. Immunobiology 191(2-3): 222-223, 1994