EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Hemoglobin Fannin-Lubbock [alpha2 beta 2 119 (GH2) Gly replaced by Asp]. a new hemoglobin variant at the alpha1 beta 1 contact


Hemoglobin Fannin-Lubbock [alpha2 beta 2 119 (GH2) Gly replaced by Asp]. a new hemoglobin variant at the alpha1 beta 1 contact



Biochimica et Biophysica Acta 453(2): 472-477



ISSN/ISBN: 0006-3002

PMID: 11828

Hemoglobin Fannin-Lubbock was found in a 9-year-old Mexican-American female. The abnormal hemoglobin was detected as a fast-moving variant by electrophoresis on cellulose acetate at pH 8.4. Structural analysis indicated a substitution in the beta-chain of aspartic acid for glycine at position 119, a position involved in the alpha1beta1 contact of the hemoglobin tetramer. This contact between unlike chains is larger and undergoes a smaller shift during the process of oxygenation and deoxygenation that the alpha1beta2 contact (Perutz, M.F., Muirhead, H., Cox, J.M. and Goaman, L.C.G. (1968) Nature 219, 131-139). Mutations in this contact tend to cause slight or no changes in functional behavior. Apart from a mild anemia, the propositus did not exhibit any obvious clinical symptoms.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 038943922

Download citation: RISBibTeXText

Related references

Hemoglobin Fannin-Lubbock [alpha 2 beta 2 119(GH2) Gly replaced by Asp]. a slightly unstable mutant. Biochimica et Biophysica Acta 453(2): 478-483, 1976

Hemoglobin Westmead alpha 2 122(H5)His replaced by Gln beta 2: a new hemoglobin variant with the substitution in the alpha 1 beta 1 contact area. Hemoglobin 4(1): 39-52, 1980

Hemo globin fannin lubbock alpha 2 beta 2 119 gh 2 glycine replaced by aspartic acid a new hemo globin variant at the alpha 1 beta 1 contact. Biochimica et Biophysica Acta 453(2): 473-477, 1976

Hemoglobin Maputo: a new beta-chain variant (alpha 2 beta 2 47 (CD6) Asp replaced by Tyr) in combination with hemoglobin S, identified by high performance liquid chromatography (HPLC). Hemoglobin 7(5): 423-433, 1983

Hemoglobin Gavello - alpha 2 beta 2 47 (CD6) Asp replaced by Gly. a new hemoglobin variant from Polesine (Italy). Hemoglobin 1(8): 771-779, 1977

Hemoglobin-Strumica or alpha 2 112(G19) His replaced by Arg beta 2. (With an addendum: hemoglobin-J-Paris-I, alpha 2 12(A10) Ala replaced by Asp beta 2, in the same population). Biochimica et Biophysica Acta 412(1): 181-186, 1975

Hemoglobin Athens-Georgia, or alpha 2 beta 2 40(C6)Arg replaced by Lys, a hemoglobin variant with an increased oxygen affinity. Biochimica et Biophysica Acta 439(1): 70-76, 1976

Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Hemoglobin 6(1): 43-49, 1982

A new hemoglobin variant altering the alpha 1 beta 2 contact: Hb Chemilly alpha 2 beta 2 99(G1)Asp leads to Val. Febs Letters 166(1): 8-12, 1984

A new hemoglobin variant. HB Yatsushiro alpha 2 a beta 2 60 Val replaced by Leu. Biochimica et Biophysica Acta 532(1): 195-198, 1978

Effect of chloride ion on the oxygen affinity of hemoglobin York (alpha 2 beta 2(146)Pro) and S-York hybrid hemoglobin (alpha 2 beta S beta York). Role of the beta 82 lysyl and beta 146 histydyl residues in chloride binding to hemoglobin. Journal of Biological Chemistry 258(22): 13422-13424, 1983

Hb-Volga or alpha 2 beta 2 27(B9)Ala replaced by Asp. An unstable hemoglobin variant in three generations of a Dutch family. Biochimica et Biophysica Acta 439(1): 63-69, 1976

A new hemoglobin with high oxygen affinity--hemoglobin bunbury: alpha 2 beta 2 [94 (FG1) Asp replaced by Asn. Hemoglobin 7(5): 413-421, 1983

Hemoglobin Brest [beta 127 (H5)Gln----Lys] a new unstable human hemoglobin variant located at the alpha 1 beta 1 interface with specific electrophoretic behavior. Hemoglobin 12(2): 179-188, 1988

A case of association of Hb C Ziguinchor (alpha A2 beta 6-2 (A3) Glu replaced by Val beta 58 (E2) Pro replaced by Arg) with a hereditary persistence of fetal hemoglobin (HPFH). Clinical and biological results. Medecine tropicale: revue du Corps de sante colonial 47(2): 177-179, 1987