Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction induced by secretin, cholecystokinin-pancreozymin and carbachol administration

Lankisch, P.G.; Fölsch, U.R.; Köstering, H.; Creutzfeldt, W.

Zeitschrift für Gastroenterologie. Verhandlungsband 10: 51-55


ISSN/ISBN: 0172-8504
PMID: 64052
Accession: 038950237

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The effect of somatostatin on secretin-, CCK-pancreozymin-and-carbachol-stimulated pancreatic secretion was studied in eight healthy volunteers. In all instances there was a significant reduction in duodenal secretory volume after secretin without any change in bicarbonate concentration. CCK-parcreozymin and carbachol stimulated volume and enzyme secretion were significantly inhibited and gallbladder contraction was abolished by somatostatin. In three volunteers a reversible hypercoagulation during infusion of 200 mug/h cyclic somatostatin has been observed. Somatostatin inhibited the CCK-pancreozymin stimulated pancreatic enzyme secretion of anaesthesized rats.