EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Paraproteinemic variety of pure red cell aplasia: immunological studies in 1 patient


Acta Haematologica 60(4): 227-232
Paraproteinemic variety of pure red cell aplasia: immunological studies in 1 patient
A case of adult pure red cell aplasia (PRCA) with a serum IgG inhibitor to erythropoiesis and an IgG lambda M component is presented. The study of lymphocyte populations revealed a slight but definite decrease of E and EA rosettes, with dissociation between E rosettes and PHA blastic transformation of blood lymphocytes and increase of membrane IgM-bearing lymphocytes. The relationship between PRCA and paraproteinemia is discussed: it is suggested that the serum M component may derive from an immunological unbalance between T and B lymphocytes. Since a survey of the literature reveals 5 similar cases, it is suggested that paraproteinemia may be the hallmark of a particular variety of chronic PRCA 'type 1'.


Accession: 038964864

PMID: 101009



Related references

Demonstration of three distinct immunological disorders on erythropoiesis in a patient with pure red cell aplasia and autoimmune hemolytic anemia associated with thymoma. British Journal of Haematology 68(4): 473-478, 1988

Demonstration of three distinct immunological disorders on erythropoiesis in a patient with pure red cell aplasia and autoimmune haemolytic anaemia associated with thymoma. British Journal of Haematology 68(4): 473-477, 1988

Pure red cell aplasia following autoimmune haemolytic anaemia. Cell-mediated suppression of erythropoiesis as a possible pathogenesis of pure red cell aplasia. Acta Haematologica 87(1-2): 98-102, 1992

TKI-induced pure red cell aplasia: first case report of pure red cell aplasia with both imatinib and nilotinib. Esmo Open 1(3): E000058-E000058, 2016

Immunological and electron microscopic observations in a case of pure red cell aplasia. Netherlands Journal of Medicine 18(6): 279-287, 1975

Pure red cell aplasia in a patient with sle. Journal of Osaka Medical College 46(3-4): 86-89, 100-101, 1987

Pure red cell aplasia in an HIV-infected patient. Aids 6(2): 234-235, 1992

Aplastic anaemia in a patient with pure red cell aplasia. Irish Journal of Medical Science 149(5): 212-214, 1980

Autoantibodies against erythropoietin in a patient with pure red-cell aplasia. New England Journal of Medicine 334(10): 630-633, 1996

Deceptive HbA₁c in a patient with pure red cell aplasia. Lancet 382(9889): 366-366, 2013