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Parathyroid secretory protein: Immunocytochemical localisation within cells that contain parathyroid hormone


, : Parathyroid secretory protein: Immunocytochemical localisation within cells that contain parathyroid hormone. Lancet 2(8085): 371-372


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Accession: 038964881

PMID: 79733

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Weber, C.J.; Russell, J.; Costanzo, M.K.; Karp, F.; Benjamin, M.; Hardy, M.A.; Feind, C.R., 1992: Relationships of parathyroid hormone, parathyroid secretory protein, parathyroid hormone messenger RNA, parathyroid secretory protein mRNA, and replication in human parathyroid adenoma and secondary hyperplasia tissues and cultures. The purpose of this study was to clarify the relationships of extractable and secreted parathyroid hormone (PTH) and parathyroid secretory protein (PSP) in human parathyroid tumors to PTH messenger RNA (mRNA), PSP mRNA, and cell replication. In ti...

Moran, J.R.; Born, W.; Tuchschmid, C.R.; Fischer, J.A., 1981: Calcium-regulated biosynthesis of the parathyroid secretory protein, proparathyroid hormone, and parathyroid hormone in dispersed bovine parathyroid cells. Dispersed bovine parathyroid cells were incubated in vitro with 3H-labeled amino acids for 30--120 min. Analysis of cell extracts by sodium dodecyl sulfate-urea-polyacrylamide gel electrophoresis revealed a calcium-regulated incorporation of 3H-la...

Arps, H.; Dietel, M.; Lauritzen, B.; Elting, J.J.; Niendorf, A.; Cohn, D.V., 1987: Co-localization of parathyroid hormone and secretory protein-I in bovine parathyroid glands: a double immunocytochemical study at the electron microscopical level. Secretory protein-I (SP-I), also known as chromogranin A, is an acidic glycoprotein of unknown function that is found in large amount in the secretory granules of all endocrine and neuroendocrine cells, but not in exocrine or epithelial cells. It...

Stewart, A.F.; Cain, R.L.; Burr, D.B.; Jacob, D.; Turner, C.H.; Hock, J.M., 2000: Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893. Daily administration of parathyroid hormone (PTH) and PTH-related protein (PTHrP) peptides has been shown to increase bone mass and strength in animals and, for PTH, to increase bone mass in humans. Long-term direct comparison of multiple members...

Nakamoto, C.; Behar, V.; Chin, K.R.; Adams, A.E.; Suva, L.J.; Rosenblatt, M.; Chorev, M., 1995: Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor. 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone. Parathyroid hormone (PTH) regulates calcium and phosphate metabolism through a G-protein-coupled receptor which is shared with PTH-related protein (PTHrP). Therefore, structure-activity studies of PTH and PTHrP with their common receptor provide a...

Nakamoto, C.; Behar, V.; Chin, K., R.; Adams, A., E.; Suva, L., J.; Rosenblatt, M.; Chorev, M., 1995: Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor. 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone. Parathyroid hormone (PTH) regulates calcium and phosphate metabolism through a G-protein-coupled receptor which is shared with PTH-related protein (PTHrP). Therefore, structure-activity studies of PTH and PTHrP with their common receptor provide a...

Matsushita, H.; Usui, M.; Hara, M.; Shishiba, Y.; Nakazawa, H.; Honda, K.; Torigoe, K.; Kohno, K.; Kurimoto, M., 1997: Co-secretion of parathyroid hormone and parathyroid-hormone-related protein via a regulated pathway in human parathyroid adenoma cells. Parathyroid-hormone-related protein (PTHrP) is widely expressed not only in malignant tumors but also in both epithelial and nonepithelial cells of normal tissues. Secreted PTHrP is suspected to act as a paracrine or autocrine regulator. However,...

Futrell, J.M.; Roth, S.I.; Su, S.P.; Habener, J.F.; Segre, G.V.; Potts, J.T., 1979: Immunocytochemical localization of parathyroid hormone in bovine parathyroid glands and human parathyroid adenomas. Light and electron microscopic localization of parathyroid hormone (PTH) in human and bovine parathyroid tissue has been achieved using an indirect peroxidase labeled antibody method. Granular deposition of the reaction product was found throughou...

Baty, L.; Rouse, J.; Hamilton, J., 1988: Protein kinase activities in the parathyroid gland: proparathyroid hormone, parathyroid hormone and secretory protein-I as substrates for phosphorylation. We have identified two protein kinase activities in homogenates of bovine parathyroid tissue following fractionation on DEAE columns. One of these is a protein kinase C based upon its requirement for calcium and phosphatidylserine and the other on...

Matsushita, H.; Hara, M.; Endo, Y.; Shishiba, Y.; Hara, S.; Ubara, Y.; Nakazawa, H.; Suzuki, N.; Kawaminami, K.; Kido, T.; Li, Q.; Grimelius, L., 1999: Proliferation of parathyroid cells negatively correlates with expression of parathyroid hormone-related protein in secondary parathyroid hyperplasia. Background. Parathyroid hormone-related protein (PTHrP) is now suspected to act as an autocrine or paracrine regulator of cell growth or differentiation, although it was originally reported as a hypercalcemic substance in malignancies. This study...