+ Translate

Spectral density analysis of the effects of barbiturates and benzodiazepines on the electrocorticogram of the squirrel monkey

, : Spectral density analysis of the effects of barbiturates and benzodiazepines on the electrocorticogram of the squirrel monkey. Archives Internationales de Pharmacodynamie et de Therapie 223(2): 301-310

The effects of pentobarbital and diazepam were compared in a series of tests in squirrel monkeys; the effects of phenobarbital and flurazepam were compared in a second series. Observations were made of gross behavior and on the ECoG; the latter was analyzed by the spectral density technique. The two barbiturates induced sedation,which was occasionally so deep that the monkeys could not be readily aroused. The benzodiazepines induced sedation in some monkeys, but others showed signs of restlessness. The ECoG showed general slowing with the barbiturates, whereas the benzodiazepines produced mixed fast and slow patterns. Spectral density analysis showed that pentobarbital increased activity at frequencies below 40 Hz, with the largest increases occurring below 8 Hz. Phenobarbital increased activity below 8 Hz, but differed from pentobarbital by decreasing activity above 13 Hz. The benzodiazepines increased activity below 8 Hz, decreased it between 8 and 20 Hz, and increased it between 20 and 50 Hz.

(PDF 0-2 workdays service)

Accession: 038981055

PMID: 11759

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Uyeno E.T., 1971: Behavioral effects of phenothiazines and barbiturates in the squirrel monkey. Proceedings of the Western Pharmacology Society 14: 149-153

Byrd, L.D., 1980: Time-course effects of two barbiturates on cardiovascular activity and temperature in the squirrel monkey. Life Sciences 27(11): 935-942

Byrd L.D., 1980: Time course effects of 2 barbiturates on cardio vascular activity and temperature in the squirrel monkey saimiri sciureus. Heart rate (HR), mean arterial blood pressure (BP) and core temperature (TEMP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects o...

Sundt, T.M.; Michenfelder, J.D., 1971: Cerebral ATP and lactate levels with electrocorticogram correlation before, during, and after middle cerebral artery occlusion in the squirrel monkey. European Neurology 6(1): 73-77

Freeman, W.J.; Zhai, J., 2008: Simulated power spectral density (PSD) of background electrocorticogram (ECoG). The ECoG background activity of cerebral cortex in states of rest and slow wave sleep resembles broadband noise. The power spectral density (PSD) then may often conform to a power-law distribution: a straight line in coordinates of log power vs. l...

Illingworth D.R.; Portman O.W.; Whipple L.E., 1974: Metabolic interrelationships between the lipids of very low density low density and high density lipo proteins in the squirrel monkey. Biochimica et Biophysica Acta 369(3): 304-314

Maza, M.E.; Galindez, M.; Martinez, R.; Cortes, E., 1982: Mass spectral fragmentation patterns of 1 5 benzodiazepines 1. o effects of r 2 substituent on 2 o r 2 aniline 4 p r 1 phenyl 3h 1 5 benzodiazepines. The 70 eV electron impact mass spectra of twenty-five 1,5-benzodiazepines [potential tranquilizers] are discussed in detail with the aid of metastable ions and by comparison with the fragmentation patterns of known compounds. The fragmentation is...

Gulbrandsen C.L.; Wilson R.B.; Lees R.S., 1971: Conversion of human plasma very low density to low density lipo proteins in the squirrel monkey. Circulation Supplement 44(4): II-10

Stoelting, R.K., 1981: Hemodynamic effects of barbiturates and benzodiazepines. Cleveland Clinic Quarterly 48(1): 9-13

Chiu, T.H.; Rosenberg, H.C., 1995: Barbiturates and benzodiazepines Effects and mechanisms. Chang, L W , Dyer, R S Neurological Disease and Therapy; Handbook of neurotoxicology 739-767