+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Studies of experimental cervical spinal cord transection. Part III: Effects of acute cervical spinal cord transection on cerebral blood flow



Studies of experimental cervical spinal cord transection. Part III: Effects of acute cervical spinal cord transection on cerebral blood flow



Journal of Neurosurgery 50(5): 633-638



Regional cerebral blood flow (CBF) was measured by the microsphere technique in anesthetized, mechanically ventilated dogs before and after cervical laminectomy in four (control group), or cervical laminectomy followed by cervical cord transection (CCT) at the C-6 level in six (experimental group). No significant differences in arterial pH, pO2 or pCO2 were observed between control and experimental dogs. Baseline values for mean arterial pressure (MAP) were also similar in the two groups, but MAP fell in all experimental dogs after CCT (p less than 0.025). At 120 minutes after CCT, three of the six dogs had an MAP greater than 60 torr (66 +/- 4 torr), and in three the MAP was greater than 50 torr (45 +/- 3 torr). Regional CBF in cortical gray matter, white matter, and medulla did not change significantly after CCT in dogs with MAP greater than 60 torr. The CBF fell significantly at 120 minutes after CCT in all regions sampled in the dogs with MAP less than 50 torr (p less than 0.025). At 30 and 120 minutes after CCT, cerebellar blood flow fell significantly in all experimental animals (p less than 0.05). These findings indicate that, despite hypotension and sympathetic denervation of cerebral vessels, CBF in cortical gray matter, white matter, and medulla is maintained at normal levels after CCT by autoregulation as long as MAP exceeds 60 torr. Decreased cerebellar blood flow in the experimental group suggests redistribution of CBF after CCT with relative preservation of flow to gray matter, white matter, and medulla. Reduced CBF in the acutely cord-injured patient with significant hypotension (MAP less than 60 torr) may stimulate or complicate coexistent head injury.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 038982448

Download citation: RISBibTeXText

PMID: 34676

DOI: 10.3171/jns.1979.50.5.0633


Related references

Studies of experimental cervical spinal cord transection. Part II: Plasma norepinephrine levels after acute cervical spinal cord transection. Journal of Neurosurgery 50(5): 629-632, 1979

Experimental cervical spinal cord transection 4. effects of cervical spinal cord transection on myo cardial blood flow in anesthetized dogs. Journal of Neurosurgery 52(2): 197-202, 1980

Studies of experimental cervical spinal cord transection. Part I: Hemodynamic changes after acute cervical spinal cord transection. Journal of Neurosurgery 49(4): 558-562, 1978

The effect of hypocapnia and change of blood pressure on cerebral blood flow in men with cervical spinal cord transection. Journal of the Neurological Sciences 30(1): 129-136, 1976

Effects of transection of cervical spinal cord on lipopolysaccharide induced acute lung injury in rat. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20(10): 621-624, 2008

Pulmonary edema in acute transection of the cervical spinal cord. Surgery Gynecology and Obstetrics 139(3): 363-366, 1974

The mechanism of spinal cord cavitation following spinal cord transection. Part 3: Delayed grafting with and without spinal cord retransection. Journal of Neurosurgery 46(6): 757-766, 1977

The cardiovascular effects of clonidine in rabbits after cervical spinal cord transection. British Journal of Pharmacology 57(3): 449p-450p, 1976

Brain and lungs at risk after cervical spinal cord transection: intracranial pressure, brain water, blood-brain barrier permeability, cerebral blood flow, and extravascular lung water changes. Surgical Neurology 24(2): 191-205, 1985

Influence of spinal cord transection on spinal cord blood flow in rats. General Pharmacology 9(6): 463-465, 1978

Phentolamine does not attenuate the intra cranial pressure rise after experimental cervical spinal cord transection. Federation Proceedings 39(3): ABSTRACT 3631, 1980

Effect of differential spinal cord transection on human cerebral blood flow. Journal of the Neurological Sciences 47(3): 395-406, 1980

The central hypotensive action of clonidine in man studies in subjects with traumatic cervical spinal cord transection. European Journal of Clinical Investigation 6(4): 323, 1976

Pediatric arrowshot injury to cervical spinal cord-sagittal cord transection with no neurological deficit and good outcome: case report and review of literature. Child's Nervous System 29(10): 1933-1939, 2013

Control of breathing after low cervical spinal cord transection. American Review Of Respiratory Disease Part 2: 324, 1977