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6-Mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat

6-Mercaptopurine-induced alterations in mineral metabolism and teratogenesis in the rat

Teratology 34(3): 321-334

The relationship between 6-mercaptopurine-induced alterations in mineral metabolism and the teratogenic effects of the drug were investigated. Pregnant Sprague-Dawley rats were fed diets containing 4.5, 100, or 1,000 micrograms Zn per 1 g diet. On day 11 of gestation, dams were given intraperitoneal injections of 6-mercaptopurine (27.5 mg/kg). At term, dams fed the 1,000-micrograms Zn per 1 g diet showed fewer drug-induced deleterious effects on reproduction and embryogenesis than did those fed lower levels of zinc. Mineral analysis of maternal and fetal tissues revealed pronounced effects of 6-mercaptopurine on metabolism of zinc, copper, iron, calcium, and magnesium. The results of this study indicate that 6-mercaptopurine teratogenesis may be due in part to drug-induced changes in mineral metabolism.

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Accession: 039022702

Download citation: RISBibTeXText

PMID: 3798368

DOI: 10.1002/tera.1420340312

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