+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

6-Mercaptopurine: total body autoradiograms and plasma concentration-time curves of 6MP and metabolites from marmoset monkeys



6-Mercaptopurine: total body autoradiograms and plasma concentration-time curves of 6MP and metabolites from marmoset monkeys



Pediatric Hematology and Oncology 3(2): 159-165



To study the body distribution of 6-mercaptopurine (6MP), [8-14C]6MP was given by infusion to 2 marmoset monkeys at a dose rate of 5 mg/kg body weight/h for 1 and 4 h, respectively. Both experimental animals were sacrificed 2 h after the end of the drug infusion and instantly frozen at -70 degrees C. Whole-body sagittal sections were made later. Blood samples were obtained regularly during the experiments to quantitate 6MP, 6MP riboside (6MPR), 6-thioxanthine, and 6-thiouric acid in plasma. The autoradiograms revealed extensive distribution of the 14C label. High levels of radioactivity were seen in liver, bile, and intestinal contents. Labeling of the central nervous system and bone marrow was obvious. The plasma concentration-time curves of 6MP and 6MPR attained steady-state concentrations of 30-40 microM and 6-12 microM, respectively. After stopping the infusion of the drug, the concentrations of 6MP and 6MPR became equal. 6MPR contributes to the biological effect of 6MP, as degradation of 6MPR results in 6MP. In studies on the pharmacokinetics and dynamics one should try to include all relevant metabolites of 6MP, both in plasma and in the cells.

(PDF emailed within 0-6 h: $19.90)

Accession: 039022705

Download citation: RISBibTeXText

PMID: 3153226

DOI: 10.3109/08880018609031212



Related references

Effect of adenosine and its metabolites on plasma ACTH and corticosterone concentration in allopurinol or 6-mercaptopurine pretreated rats. FASEB Journal 8(4-5): A296, 1994

Studies on the total concentration of electrolytes and total concentration of some inorganic ions in the plasma of the desert mammal Jaculus jaculus in relation to the body water balance. Bulletin de l'Institut du Desert. 1961 ; 11(2): 1-8, 1967

Plasma beta cell tropin concentrations of obese rhesus monkeys correlation with plasma insulin concentration and body weight. Journal of Endocrinology 123(SUPPL): 116, 1989

Mono- and biphasic plasma concentration-time curves of mesalazine from a 500 mg suppository in healthy male volunteers controlled by the time of defecation before dosing. Journal of Pharmacy & Pharmacology 52(6): 645-652, June, 2000

Interpretation of plasma concentration-time curves after oral dosing. Journal of Pharmaceutical Sciences 66(2): 178-180, 1977

Monitoring of clozapine and norclozapine plasma concentration-time curves in acute overdose. Journal of Toxicology Clinical Toxicology 38(3): 325-328, April, 2000

Effects of protein bindings of drugs on areas under plasma concentration--time curves. Journal of Pharmaceutical Sciences 61(1): 138-139, 1972

The effect on fetal development and the plasma concentration time curves of bromofenofos and its metabolite in rats. Teratology 38(5): 514, 1988

Concentration of catechol amines in the tissues of Macaca monkeys in the early periods following total-body gamma-irradiation. Radiobiologiya 5(4): 494-500, 1965

Preparation of mean drug concentration--time curves in plasma. A study on the frequency distribution of pharmacokinetic parameters. Chemical and Pharmaceutical Bulletin 33(4): 1620-1632, 1985

Arteriolar, capillary, and venular FITC-dextran time-concentration curves and plasma flow velocities. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 161(3): 370-377, 1979

Labeled red blood cell and plasma time concentration curves at arteriolar bifurcations with endo toxin. Federation Proceedings 43(3): ABSTRACT 224, 1984

The assay of plasma concentration of thioridazine and its metabolites as a function of time. Communications in Psychopharmacology 2(6): 475-479, 1978

Direct approximation of plasma concentration time curves of e diethylstilbestrol monoglucuronide after oral and intravenous administration of fosfestrol. Die Pharmazie 41(12): 862-864, 1986

Direct approximation of plasma concentration time curves of 3-diethylstilbestrol monoglucuronide following oral and intravenous administration of fosfestrol. Die Pharmazie 41(12): 862-864, 1986